4-hydroxy-4-azatricyclo[5.2.1.0(2,6)]decane-3,5-dione -Drug Synthesis Database

【结构式】

【分子编号】34832

【品名】4-hydroxy-4-azatricyclo[5.2.1.0(2,6)]decane-3,5-dione

【CA登记号】

【分子式】C₉H₁₁NO₃

【分子量】181.19128

【元素组成】C 59.66% H 6.12% N 7.73% O 26.49%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(A)

The condensation of N-(benzyloxycarbonyl)-L-glutamic acid bis(2,4,6-trichlorophenyl) ester (I) with taurine (II) in the presence of NaOH provided diamide (III). After deprotection of the benzyloxycarbonyl group of (III) by hydrogenolysis over Pd/C, the resulting amine (IV) was coupled with N-palmitoyl-S-(2,3-dilauroyloxypropyl)cysteine (V) using N,N'-dicyclohexylcarbodiimide and N-hydroxynorbornan-2,3-dicarboximide (A) to furnish the title compound.

参考文献中间体

合成目标

【1】 Baschang, G.; Hartmann, A. (Novartis AG); Aminosulphonic acid derivs. and process for their preparation. EP 0548024; JP 1993255239; US 5342977 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	34832	4-hydroxy-4-azatricyclo[5.2.1.0(2,6)]decane-3,5-dione		C₉H₁₁NO₃	详情	详情
(I)	34827	bis(2,4,6-trichlorophenyl) (2S)-2-[[(benzyloxy)carbonyl]amino]pentanedioate		C₂₅H₁₇Cl₆NO₆	详情	详情
(II)	34828	2-amino-1-ethanesulfonic acid	107-35-7	C₂H₇NO₃S	详情	详情
(III)	34829	disodium 2-([(2S)-2-[[(benzyloxy)carbonyl]amino]-5-oxo-5-[(2-sulfonatoethyl)amino]pentanoyl]amino)-1-ethanesulfonate		C₁₇H₂₃N₃Na₂O₁₀S₂	详情	详情
(IV)	34830	disodium 2-([(2S)-2-amino-5-oxo-5-[(2-sulfonatoethyl)amino]pentanoyl]amino)-1-ethanesulfonate		C₉H₁₇N₃Na₂O₈S₂	详情	详情
(V)	34831	(2R)-3-[[(2R)-2,3-bis(dodecanoyloxy)propyl]sulfanyl]-2-(palmitoylamino)propionic acid		C₄₆H₈₇NO₇S	详情	详情

Extended Information