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【结 构 式】 
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【分子编号】34831 【品名】(2R)-3-[[(2R)-2,3-bis(dodecanoyloxy)propyl]sulfanyl]-2-(palmitoylamino)propionic acid 【CA登记号】 |
【 分 子 式 】C46H87NO7S 【 分 子 量 】798.26532 【元素组成】C 69.21% H 10.99% N 1.75% O 14.03% S 4.02% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)The condensation of N-(benzyloxycarbonyl)-L-glutamic acid bis(2,4,6-trichlorophenyl) ester (I) with taurine (II) in the presence of NaOH provided diamide (III). After deprotection of the benzyloxycarbonyl group of (III) by hydrogenolysis over Pd/C, the resulting amine (IV) was coupled with N-palmitoyl-S-(2,3-dilauroyloxypropyl)cysteine (V) using N,N'-dicyclohexylcarbodiimide and N-hydroxynorbornan-2,3-dicarboximide (A) to furnish the title compound.
| 【1】 Baschang, G.; Hartmann, A. (Novartis AG); Aminosulphonic acid derivs. and process for their preparation. EP 0548024; JP 1993255239; US 5342977 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 34832 | 4-hydroxy-4-azatricyclo[5.2.1.0(2,6)]decane-3,5-dione | C9H11NO3 | 详情 | 详情 | |
| (I) | 34827 | bis(2,4,6-trichlorophenyl) (2S)-2-[[(benzyloxy)carbonyl]amino]pentanedioate | C25H17Cl6NO6 | 详情 | 详情 | |
| (II) | 34828 | 2-amino-1-ethanesulfonic acid | 107-35-7 | C2H7NO3S | 详情 | 详情 |
| (III) | 34829 | disodium 2-([(2S)-2-[[(benzyloxy)carbonyl]amino]-5-oxo-5-[(2-sulfonatoethyl)amino]pentanoyl]amino)-1-ethanesulfonate | C17H23N3Na2O10S2 | 详情 | 详情 | |
| (IV) | 34830 | disodium 2-([(2S)-2-amino-5-oxo-5-[(2-sulfonatoethyl)amino]pentanoyl]amino)-1-ethanesulfonate | C9H17N3Na2O8S2 | 详情 | 详情 | |
| (V) | 34831 | (2R)-3-[[(2R)-2,3-bis(dodecanoyloxy)propyl]sulfanyl]-2-(palmitoylamino)propionic acid | C46H87NO7S | 详情 | 详情 |
Extended Information