【结 构 式】 |
【分子编号】31977 【品名】1-ethylbenzene 【CA登记号】100-41-4 |
【 分 子 式 】C8H10 【 分 子 量 】106.1674 【元素组成】C 90.51% H 9.49% |
合成路线1
该中间体在本合成路线中的序号:(I)The copolymerization of ethylene (III) and maleic anhydride (II) in ethylbenzene (I) by means of benzoyl peroxide (IV) at 70 C gives an ethylene/maleic anhydride copolymer (V), which is ammoniated by treating with liquid ammonia in acetone yielding the ammoniated ethylene/maleic acid copolymer (VI). Finally, this product is imidated partially by heating in refluxing xylene.
【1】 Asculai, S.S.; Fields, J.E.; Johnson, R.K.; Johnson, J.H.; Carboxyimidate, a low-molecular-weight polyelectrolyte with antitumor properties and low toxixity. J Med Chem 1982, 25, 9, 1060-64. |
【2】 Hopkins, S.J.; Castaner, J.; Serradell, M.N.; Blancafort, P.; N-137. Drugs Fut 1983, 8, 3, 210. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 31977 | 1-ethylbenzene | 100-41-4 | C8H10 | 详情 | 详情 |
(II) | 11182 | 2,5-Furandione; Maleic anhydride | 108-31-6 | C4H2O3 | 详情 | 详情 |
(III) | 18363 | 4-chloro-2-methyl-5-(methylsulfonyl)benzoic acid | C9H9ClO4S | 详情 | 详情 | |
(IV) | 35970 | benzoyl benzenecarboperoxoate | 94-36-0 | C14H10O4 | 详情 | 详情 |
(V) | 35971 | 3-[2-(2,5-dioxotetrahydro-3-furanyl)ethyl]-4-(1-phenylethyl)dihydro-2,5-furandione | C18H18O6 | 详情 | 详情 | |
(VI) | 35972 | C18H26N3O6 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号:(VII)This compound can be obtained by several different ways: 1) By condensation of 4-ethylpropiophenone (I), formaldehyde (II) and piperidine (III) in refluxing isopropanol. 2) By reaction of 4-ethyl-alpha-methyl-beta-chloropropiophenone (IV) with (III) in refluxing ethanol. 3) By cyclization of 4-ethyl-alpha-methyl-beta-amino-propiophenone (V) with 1,5-dibromopentane (VI) in hot ethanol. 4) By a Friedel-Kraft's reaction of ethylbenzene (VII) with 3-piperidinoisobutyryl chloride (VIII) by means of AlCl3 at reflux temperature. 5) By condensation of 4-ethyl-alpha-methylenepropiophenone (IX) with (III) in ethanol.
【1】 Murakami, M.; Sone, T.; Sako, K.; Wakabayashi, M.; Kodaira, R.; JP 7925571 . |
【2】 Murakami, M.; Sone, T.; Sako, K.; Wakabayashi, M.; Kodaira, R.; Preparation of propiophenone derivative. JP 54036274 . |
【3】 Murakami, M.; Sone, T.; Sako, K.; Wakabayashi, M.; Kodaira, R.; Novel preparation of piperidine derivatives. JP 54032480 . |
【4】 Murakami, M.; Sone, T.; Sako, K.; Wakabayashi, M.; Kodaira, R; Preparation of propiophenone derivative. JP 54030178 . |
【5】 Morita, E.; Kanai, T.; Amino-substituted propiophenone derivatives and medicaments containing same. JP 52085175 . |
【6】 Morita, E.; Kanai, T. (Eisai Co., Ltd.); Propiophenone derivatives in the treatment of pathological muscular conditions. US 3995047; US 4181803 . |
【7】 Castaner, J.; Blancafort, P.; Serradell, M.N.; EMPP. Drugs Fut 1982, 7, 2, 105. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 22076 | 1-(4-ethylphenyl)-1-propanone | 27465-51-6 | C11H14O | 详情 | 详情 |
(II) | 22075 | Formaldehyde; Paraformaldehyde | 1118-66-7 | CH2O | 详情 | 详情 |
(III) | 10158 | Piperidine | 110-89-4 | C5H11N | 详情 | 详情 |
(IV) | 31975 | 3-chloro-1-(4-ethylphenyl)-2-methyl-1-propanone | C12H15ClO | 详情 | 详情 | |
(V) | 31976 | 3-amino-1-(4-ethylphenyl)-2-methyl-1-propanone | C12H17NO | 详情 | 详情 | |
(VI) | 30560 | 1,5-dibromopentane | 111-24-0 | C5H10Br2 | 详情 | 详情 |
(VII) | 31977 | 1-ethylbenzene | 100-41-4 | C8H10 | 详情 | 详情 |
(VIII) | 31978 | 2-methyl-3-(1-piperidinyl)propanoyl chloride | C9H16ClNO | 详情 | 详情 | |
(IX) | 31979 | 1-(4-ethylphenyl)-2-methyl-2-propen-1-one | C12H14O | 详情 | 详情 |