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【结 构 式】

【分子编号】31979

【品名】1-(4-ethylphenyl)-2-methyl-2-propen-1-one

【CA登记号】

【 分 子 式 】C12H14O

【 分 子 量 】174.24256

【元素组成】C 82.72% H 8.1% O 9.18%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IX)

This compound can be obtained by several different ways: 1) By condensation of 4-ethylpropiophenone (I), formaldehyde (II) and piperidine (III) in refluxing isopropanol. 2) By reaction of 4-ethyl-alpha-methyl-beta-chloropropiophenone (IV) with (III) in refluxing ethanol. 3) By cyclization of 4-ethyl-alpha-methyl-beta-amino-propiophenone (V) with 1,5-dibromopentane (VI) in hot ethanol. 4) By a Friedel-Kraft's reaction of ethylbenzene (VII) with 3-piperidinoisobutyryl chloride (VIII) by means of AlCl3 at reflux temperature. 5) By condensation of 4-ethyl-alpha-methylenepropiophenone (IX) with (III) in ethanol.

1 Murakami, M.; Sone, T.; Sako, K.; Wakabayashi, M.; Kodaira, R.; JP 7925571 .
2 Murakami, M.; Sone, T.; Sako, K.; Wakabayashi, M.; Kodaira, R.; Preparation of propiophenone derivative. JP 54036274 .
3 Murakami, M.; Sone, T.; Sako, K.; Wakabayashi, M.; Kodaira, R.; Novel preparation of piperidine derivatives. JP 54032480 .
4 Murakami, M.; Sone, T.; Sako, K.; Wakabayashi, M.; Kodaira, R; Preparation of propiophenone derivative. JP 54030178 .
5 Morita, E.; Kanai, T.; Amino-substituted propiophenone derivatives and medicaments containing same. JP 52085175 .
6 Morita, E.; Kanai, T. (Eisai Co., Ltd.); Propiophenone derivatives in the treatment of pathological muscular conditions. US 3995047; US 4181803 .
7 Castaner, J.; Blancafort, P.; Serradell, M.N.; EMPP. Drugs Fut 1982, 7, 2, 105.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 22076 1-(4-ethylphenyl)-1-propanone 27465-51-6 C11H14O 详情 详情
(II) 22075 Formaldehyde; Paraformaldehyde 1118-66-7 CH2O 详情 详情
(III) 10158 Piperidine 110-89-4 C5H11N 详情 详情
(IV) 31975 3-chloro-1-(4-ethylphenyl)-2-methyl-1-propanone C12H15ClO 详情 详情
(V) 31976 3-amino-1-(4-ethylphenyl)-2-methyl-1-propanone C12H17NO 详情 详情
(VI) 30560 1,5-dibromopentane 111-24-0 C5H10Br2 详情 详情
(VII) 31977 1-ethylbenzene 100-41-4 C8H10 详情 详情
(VIII) 31978 2-methyl-3-(1-piperidinyl)propanoyl chloride C9H16ClNO 详情 详情
(IX) 31979 1-(4-ethylphenyl)-2-methyl-2-propen-1-one C12H14O 详情 详情
Extended Information