3-[2-(2,5-dioxotetrahydro-3-furanyl)ethyl]-4-(1-phenylethyl)dihydro-2,5-furandione -Drug Synthesis Database

【结构式】

【分子编号】35971

【品名】3-[2-(2,5-dioxotetrahydro-3-furanyl)ethyl]-4-(1-phenylethyl)dihydro-2,5-furandione

【CA登记号】

【分子式】C₁₈H₁₈O₆

【分子量】330.33732

【元素组成】C 65.45% H 5.49% O 29.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

The copolymerization of ethylene (III) and maleic anhydride (II) in ethylbenzene (I) by means of benzoyl peroxide (IV) at 70 C gives an ethylene/maleic anhydride copolymer (V), which is ammoniated by treating with liquid ammonia in acetone yielding the ammoniated ethylene/maleic acid copolymer (VI). Finally, this product is imidated partially by heating in refluxing xylene.

参考文献中间体

合成目标

【1】 Asculai, S.S.; Fields, J.E.; Johnson, R.K.; Johnson, J.H.; Carboxyimidate, a low-molecular-weight polyelectrolyte with antitumor properties and low toxixity. J Med Chem 1982, 25, 9, 1060-64.
【2】 Hopkins, S.J.; Castaner, J.; Serradell, M.N.; Blancafort, P.; N-137. Drugs Fut 1983, 8, 3, 210.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	31977	1-ethylbenzene	100-41-4	C₈H₁₀	详情	详情
(II)	11182	2,5-Furandione; Maleic anhydride	108-31-6	C₄H₂O₃	详情	详情
(III)	18363	4-chloro-2-methyl-5-(methylsulfonyl)benzoic acid		C₉H₉ClO₄S	详情	详情
(IV)	35970	benzoyl benzenecarboperoxoate	94-36-0	C₁₄H₁₀O₄	详情	详情
(V)	35971	3-[2-(2,5-dioxotetrahydro-3-furanyl)ethyl]-4-(1-phenylethyl)dihydro-2,5-furandione		C₁₈H₁₈O₆	详情	详情
(VI)	35972			C₁₈H₂₆N₃O₆	详情	详情

Extended Information