(1S,9R,10R,11S)-17-(cyclobutylmethyl)-4-hydroxy-11-methyl-17-azatetracyclo[7.5.3.0(1,10).0(2,7)]heptadeca-2,4,6-trien-13-one -Drug Synthesis Database

【结构式】

【分子编号】31699

【品名】(1S,9R,10R,11S)-17-(cyclobutylmethyl)-4-hydroxy-11-methyl-17-azatetracyclo[7.5.3.0(1,10).0(2,7)]heptadeca-2,4,6-trien-13-one

【CA登记号】

【分子式】C₂₂H₂₉NO₂

【分子量】339.4778

【元素组成】C 77.84% H 8.61% N 4.13% O 9.43%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

By a Wittig condensation of 17-cyclobutylmethyl-3-hydroxy-8beta-methyl morphinan-6-one (I) with triphenylmethylenephosphorane in DMSO.

【1】 Kotick, M.P.; Polazzi, J.O. (Bayer Corp.); 17-Cyclobutylmethyl-3-hydroxy-beta-methyl-6-methylene morphinane, and methods of treating pain with them. CA 1128508; EP 0027925; ES 8107222; US 4259329 .
【2】 Serradell, M.N.; Blancafort, P.; Castaner, J.; TR-5379. Drugs Fut 1982, 7, 1, 40.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	31699	(1S,9R,10R,11S)-17-(cyclobutylmethyl)-4-hydroxy-11-methyl-17-azatetracyclo[7.5.3.0(1,10).0(2,7)]heptadeca-2,4,6-trien-13-one		C₂₂H₂₉NO₂	详情	详情
(II)	27301	methylene(triphenyl)phosphorane		C₁₉H₁₇P	详情	详情

Extended Information