|
【结 构 式】 
|
【药物名称】Xorphanol, TR-5379 【化学名称】17-Cyclobutylmethyl-3-hydroxy-6-methylene-8beta-methylmorphinan 【CA登记号】77287-89-9, 77287-90-2 (mesylate) 【 分 子 式 】C23H31NO 【 分 子 量 】337.50962 |
【开发单位】Pars (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Opioid Analgesics |
合成路线1
By a Wittig condensation of 17-cyclobutylmethyl-3-hydroxy-8beta-methyl morphinan-6-one (I) with triphenylmethylenephosphorane in DMSO.
| 【1】 Kotick, M.P.; Polazzi, J.O. (Bayer Corp.); 17-Cyclobutylmethyl-3-hydroxy-beta-methyl-6-methylene morphinane, and methods of treating pain with them. CA 1128508; EP 0027925; ES 8107222; US 4259329 . |
| 【2】 Serradell, M.N.; Blancafort, P.; Castaner, J.; TR-5379. Drugs Fut 1982, 7, 1, 40. |
Extended Information