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【结 构 式】 
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【分子编号】31202 【品名】1,1'-biphenyl 【CA登记号】92-52-4 |
【 分 子 式 】C12H10 【 分 子 量 】154.2114 【元素组成】C 93.46% H 6.54% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(I)Felbinac ethyl can be obtained in two different ways: 1) The Friedel-Craft's condensation of 2-chloro-2-(methylthio)acetic acid ethyl ester (I) with biphenyl (II) by means of SnCl4 in dichloromethane gives 2-(methylthio)-4-biphenylylacetic acid ethyl ester (III), which is reduced with Zn in acetic acid. 2) By condensation of diazoacetic acid ethyl ester (V) with 4-biphenylyldichloroborane (VI) in THF.
| 【1】 Purcell, T.A.; Rivron, L.; Zard, L. (Sanofi-Synthelabo ); Method for the preparation of 4-biphenylacetic acids. AU 8782884; EP 0272981; FR 2608206; JP 1988185975; US 4810723 . |
| 【2】 Hooz, J.; Bridson, J.N.; Calzada, J.G.; Brown, H.C.; Midland, M.M.; Levy, A.B.; The reaction of alkyl- and aryldichloroboranes with ethyl diazoacetate at low temperature. J Org Chem 1973, 38, 14, 2574-76. |
| 【3】 Prous, J.; Castaner, J.; LM-001. Drugs Fut 1990, 15, 11, 1077. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 31202 | 1,1'-biphenyl | 92-52-4 | C12H10 | 详情 | 详情 |
| (II) | 21726 | ethyl 2-chloro-2-(methylsulfanyl)acetate | C5H9ClO2S | 详情 | 详情 | |
| (III) | 31203 | ethyl 2-[1,1'-biphenyl]-4-yl-2-(methylsulfanyl)acetate | C17H18O2S | 详情 | 详情 | |
| (IV) | 31204 | 4-(dichloroboryl)-1,1'-biphenyl | C12H9BCl2 | 详情 | 详情 | |
| (V) | 31205 | 2-Diazoacetic acid ethyl ester | C4H6N2O2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(I)By condensation of biphenyl (I) and succinic anhydride (II) in nitrobenzene, using AlCl3, as catalyst.
| 【1】 Castañer, J.; Fenbufen. Drugs Fut 1976, 1, 1, 21. |
| 【2】 Tomeufeik, A.; et al. (American Cyanamid Co.); Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain. DE 2147111; FR 2107848; GB 1320076; US 3784701 . |
Extended Information