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【结 构 式】 
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【药物名称】Fenbufen, CL-82204, Lederfen, Cinopal 【化学名称】4-(4-Biphenylyl)-4-oxobutyric acid 【CA登记号】36330-85-5 【 分 子 式 】C16H14O3 【 分 子 量 】254.28818 |
【开发单位】Wyeth Pharmaceuticals (Originator) 【药理作用】Ankylosing Spondylitis, Treatment of, Antiarthritic Drugs, Osteoarthritis, Treatment of, Rheumatoid Arthritis, Treatment of, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Non-Steroidal Antiinflammatory Drugs |
合成路线1
By condensation of biphenyl (I) and succinic anhydride (II) in nitrobenzene, using AlCl3, as catalyst.
| 【1】 Castañer, J.; Fenbufen. Drugs Fut 1976, 1, 1, 21. |
| 【2】 Tomeufeik, A.; et al. (American Cyanamid Co.); Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain. DE 2147111; FR 2107848; GB 1320076; US 3784701 . |
Extended Information