【结 构 式】 |
【分子编号】30601 【品名】1-(1-adamantyl)-1-ethanone oxime 【CA登记号】 |
【 分 子 式 】C12H19NO 【 分 子 量 】193.289 【元素组成】C 74.57% H 9.91% N 7.25% O 8.28% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)The compound can be obtained by two different ways: 1) The reaction of 1-acetyladamantane (I) with hydroxylamine gives the corresponding oxime (II), which is then reduced with LiAlH4 in THF. 2) By reaction of (I) with ammonia and H2 with a catalyst of Co on diatomite.
【1】 Brake, L.D. (DuPont Pharmaceuticals Co.); Verfahren zur Herstellung von alpha-Methyl-polycyclomethylaminen. CH 495944; DE 1668571; FR 1568056; US 3489802 . |
【2】 Prichard, W.W. (DuPont Pharmaceuticals Co.); Adamantanes and tricyclo[4.3.1.1(3,8)]undecanes. FR 1572956; GB 1069563; NL 6408505; US 3352912 . |
【3】 Serradell, M.N.; Castaner, J.; Robinson, C.P.; Rimantadine Hydrochloride. Drugs Fut 1984, 9, 9, 660. |
Extended Information