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【结 构 式】 
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【药物名称】Rimantadine hydrochloride, EXP-126, Oclovir, Flumadine, Roflual 【化学名称】alpha-Methyl-1-adamantanemethylamine hydrochloride 【CA登记号】1501-84-4, 13392-28-4 (free base) 【 分 子 式 】C12H22ClN 【 分 子 量 】215.76884 |
【开发单位】Bristol-Myers Squibb (Originator), Roche (Originator), Forest (Licensee) 【药理作用】ANTIINFECTIVE THERAPY, Anti-Influenza A Virus Drugs, Anti-Influenza Virus Drugs, Antiviral Drugs |
合成路线1
The compound can be obtained by two different ways: 1) The reaction of 1-acetyladamantane (I) with hydroxylamine gives the corresponding oxime (II), which is then reduced with LiAlH4 in THF. 2) By reaction of (I) with ammonia and H2 with a catalyst of Co on diatomite.
| 【1】 Brake, L.D. (DuPont Pharmaceuticals Co.); Verfahren zur Herstellung von alpha-Methyl-polycyclomethylaminen. CH 495944; DE 1668571; FR 1568056; US 3489802 . |
| 【2】 Prichard, W.W. (DuPont Pharmaceuticals Co.); Adamantanes and tricyclo[4.3.1.1(3,8)]undecanes. FR 1572956; GB 1069563; NL 6408505; US 3352912 . |
| 【3】 Serradell, M.N.; Castaner, J.; Robinson, C.P.; Rimantadine Hydrochloride. Drugs Fut 1984, 9, 9, 660. |
Extended Information