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【结 构 式】 
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【分子编号】30600 【品名】1-(1-adamantyl)-1-ethanone; 1-Adamantyl methyl ketone; 1-acetyladamantane 【CA登记号】1660-04-4 |
【 分 子 式 】C12H18O 【 分 子 量 】178.27432 【元素组成】C 80.85% H 10.18% O 8.97% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(I)The compound can be obtained by two different ways: 1) The reaction of 1-acetyladamantane (I) with hydroxylamine gives the corresponding oxime (II), which is then reduced with LiAlH4 in THF. 2) By reaction of (I) with ammonia and H2 with a catalyst of Co on diatomite.
| 【1】 Brake, L.D. (DuPont Pharmaceuticals Co.); Verfahren zur Herstellung von alpha-Methyl-polycyclomethylaminen. CH 495944; DE 1668571; FR 1568056; US 3489802 . |
| 【2】 Prichard, W.W. (DuPont Pharmaceuticals Co.); Adamantanes and tricyclo[4.3.1.1(3,8)]undecanes. FR 1572956; GB 1069563; NL 6408505; US 3352912 . |
| 【3】 Serradell, M.N.; Castaner, J.; Robinson, C.P.; Rimantadine Hydrochloride. Drugs Fut 1984, 9, 9, 660. |
合成路线2
该中间体在本合成路线中的序号：(I)The title thiosemicarbazone is prepared by condensation of 1-acetyladamantane (I) with thiosemicarbazide (II) in refluxing MeOH.
| 【1】 Kolocouris, A.; et al.; New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones- thiocarbonohydrazones: Cell growth inhibitory, antiviral and antimicrobial activity evaluation. Bioorg Med Chem Lett 2002, 15, 5, 723. |
Extended Information