(2,3-dimethylphenyl)(1H-imidazol-4-yl)methanol -Drug Synthesis Database

【结构式】

【分子编号】29033

【品名】(2,3-dimethylphenyl)(1H-imidazol-4-yl)methanol

【CA登记号】

【分子式】C₁₂H₁₄N₂O

【分子量】202.25604

【元素组成】C 71.26% H 6.98% N 13.85% O 7.91%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The Grignard condensation of imidazole-4-carboxaldehyde (I) with 2,3-dimethylphenylmagnesium bromide (II) in THF gives 4-(alpha-hydroxy-2,3-dimethylbenzyl)imidazole (III), which is then hydrogenated with H2 over Pd/C in aqueous 4N HCl.

参考文献中间体

合成目标

【1】 Karjalainen, A.J.; Kurkela, K.O.A. (Orion Corporation); 4-Benzyl- and 4-benzoyl-substituted imidazole derivatives and use as medicaments. DD 152548; EP 0024829; JP 56032463; US 4443466 .
【2】 Castaner, J.; Serradell, M.N.; Detomidine Hydrochloride. Drugs Fut 1985, 10, 1, 17.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	29032	1H-imidazole-4-carbaldehyde	C₄H₄N₂O	详情	详情
(II)	27999	bromo(2,3-dimethylphenyl)magnesium	C₈H₉BrMg	详情	详情
(III)	29033	(2,3-dimethylphenyl)(1H-imidazol-4-yl)methanol	C₁₂H₁₄N₂O	详情	详情

Extended Information