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【结 构 式】 
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【药物名称】Detomidine hydrochloride, Domosedan 【化学名称】5-[(2,3-dimethylphenyl)methyl]-1H-imidazole hydrochloride 【CA登记号】90038-01-0, 76631-46-4 (free base) 【 分 子 式 】C12H15ClN2 【 分 子 量 】222.71975 |
【开发单位】Orion Pharma (Originator) 【药理作用】PSYCHOPHARMACOLOGIC DRUGS, Sedative/Hypnotics, Sleep Disorders, Treatment of |
合成路线1
The Grignard condensation of imidazole-4-carboxaldehyde (I) with 2,3-dimethylphenylmagnesium bromide (II) in THF gives 4-(alpha-hydroxy-2,3-dimethylbenzyl)imidazole (III), which is then hydrogenated with H2 over Pd/C in aqueous 4N HCl.
| 【1】 Karjalainen, A.J.; Kurkela, K.O.A. (Orion Corporation); 4-Benzyl- and 4-benzoyl-substituted imidazole derivatives and use as medicaments. DD 152548; EP 0024829; JP 56032463; US 4443466 . |
| 【2】 Castaner, J.; Serradell, M.N.; Detomidine Hydrochloride. Drugs Fut 1985, 10, 1, 17. |
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