2,4-dihydroxybenzonitrile -Drug Synthesis Database

【结构式】

【分子编号】25403

【品名】2,4-dihydroxybenzonitrile

【CA登记号】

【分子式】C₇H₅NO₂

【分子量】135.12224

【元素组成】C 62.22% H 3.73% N 10.37% O 23.68%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Nitrile (II) was prepared by reaction of 2,4-dihydroxybenzaldehyde (I) with nitroethane and NaOAc in boiling AcOH. Subsequent condensation with D-cysteine (III) in the presence of phosphate buffer at pH 5.95 in MeOH provided the title thiazolidine.

参考文献中间体

合成目标

【1】 Bergeron, R.J.; Wiegand, J.; Weimar, W.R.; Vinson, J.R.; Bussenius, J.; Yao, G.W.; McManis, J.S.; Desazadesmethyldesferrithiocin analogues as orally effective iron chelators. J Med Chem 1999, 42, 1, 95.
【2】 Bergeron, R.J. Jr. (University of Florida); Thiazoline acid derivs.. WO 0012493 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	20094	2,4-dihydroxybenzaldehyde	95-01-2	C₇H₆O₃	详情	详情
(II)	25403	2,4-dihydroxybenzonitrile		C₇H₅NO₂	详情	详情
(III)	25404	D-cysteine; (S)-2-Amino-3-mercaptopropionic acid	921-01-7	C₃H₇NO₂S	详情	详情

Extended Information