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【结 构 式】 
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【药物名称】 【化学名称】2-(2,4-Dihydroxyphenyl)-4,5-dihydrothiazole-4(S)-carboxylic acid 【CA登记号】57980-69-5 (undefined isomer) 【 分 子 式 】C10H9NO4S 【 分 子 量 】239.25153 |
【开发单位】University of Florida (Originator) 【药理作用】Antagonists to Metals, Specific Antidotes, TREATMENT OF POISONING, DRUG ABUSE & DEPENDENCY |
合成路线1
Nitrile (II) was prepared by reaction of 2,4-dihydroxybenzaldehyde (I) with nitroethane and NaOAc in boiling AcOH. Subsequent condensation with D-cysteine (III) in the presence of phosphate buffer at pH 5.95 in MeOH provided the title thiazolidine.
| 【1】 Bergeron, R.J.; Wiegand, J.; Weimar, W.R.; Vinson, J.R.; Bussenius, J.; Yao, G.W.; McManis, J.S.; Desazadesmethyldesferrithiocin analogues as orally effective iron chelators. J Med Chem 1999, 42, 1, 95. |
| 【2】 Bergeron, R.J. Jr. (University of Florida); Thiazoline acid derivs.. WO 0012493 . |
Extended Information