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【结 构 式】 
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【分子编号】24920 【品名】tributyl(vinyl)stannane；Tributylvinylstannane;Vinyltributylstannane 【CA登记号】7486-35-3 |
【 分 子 式 】C14H30Sn 【 分 子 量 】317.1022 【元素组成】C 53.03% H 9.54% Sn 37.44% |
合成路线1
该中间体在本合成路线中的序号：(XII)Benzylic bromination of 3-bromo-o-xylene (IX) with NBS in the presence of benzoyl peroxide in refluxing CCl4 or chlorobenzene at 80 °C gives 1-bromo-2,3-bis(bromomethyl)benzene (X), which then cyclizes with benzylamine in the presence of KHCO3 in acetonitrile to yield 2-benzyl-4-bromoisoindoline (XI). Alkenylation of compound (XI) with tributyl(vinyl)tin (XII) by means of Pd(PPh3)4 in toluene provides the isoindoline (XIII), which is then deprotected by means of 1-chloroethyl chloroformate (ACE-Cl) in refluxing 1,2-dichloroethane to afford 4-vinylisoindoline (XIV). Finally, coupling of 4-vinylisoindoline (XIV) with N-Boc-trans-4-hydroxyproline methyl ester (XV), previously activated with CDI, in DMF at 60 °C results in carbamate (XVI) .
Alternatively, debenzylation of 2-benzyl-4-bromoisoindoline (XI) by means of ACE-Cl in chlorobenzene at 90 °C, followed by condensation of the deprotected isoindoline (XVII) with N-Boc-trans-4-hydroxyproline methyl ester (XV), previously treated with CDI, by means of DIEA in DMF at 50 °C furnishes carbamate (XVIII). Then, alkenylation of the aryl bromide (XVIII) with potassium vinyltrifluoroborate (XIX) and Et3N in refluxing EtOH affords the vinyl isoindoline derivative (XVI) .
Finally, Boc-deprotection of proline derivative (XVI) by means of HCl in dioxane gives the corresponding amine (XX), which is then coupled with the L-tert-leucine carbamate derivative (XXI) in the presence of EDC, DIEA and HOAt or HOBt in DMF to yield the building block diene (I) .
The L-tert-leucine carbamate (XXI) is prepared by alkylation of ethyl isobutyrate (XXII) with 4-bromo-1-butene (XXIII) and LDA in HMPA, followed by ester group reduction with LiAlH4 in Et2O, affording 2,2-dimethyl-5-hexen-1-ol (XXIV) . After treatment of hexenol (XXIV) with triphosgene by means of DIEA and NaOH in 1,4-dioxane, the resulting chloroformate is condensed with L-tert-leucine (XXV) to give carbamate (XXI) .
| 【1】 Holloway, M.K., Liverton, N.J., Ludmerer, S.W. et al. (Merck & Co., Inc.). HCV NS3 protease inhibitors. EP 1910404, EP 924593, JP 2009502793, US 2007027071, WO 2007015787, WO 2007015855. |
| 【2】 McCauley, J.A., McIntyre, C.J., Rudd, M.T. et al. Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor. J Med Chem 2010, 53(6): 2443-63. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 69055 | (3S,5R)-1-(2-((((2,2-dimethylhex-5-en-1-yl)oxy)carbonyl)amino)-3,3-dimethylbutanoyl)-5-(methoxycarbonyl)pyrrolidin-3-yl 4-vinylisoindoline-2-carboxylate | C32H45N3O7 | 详情 | 详情 | |
| (IX) | 69063 | 3-bromo-o-xylene;2,3-Dimethylbromobenzene;3-Bromo-1,2-dimethylbenzene | 576-23-8 | C8H9Br | 详情 | 详情 |
| (X) | 69064 | 1-bromo-2,3-bis(bromomethyl)benzene | C8H7Br3 | 详情 | 详情 | |
| (XI) | 69065 | 2-benzyl-4-bromoisoindoline | C15H14BrN | 详情 | 详情 | |
| (XII) | 24920 | tributyl(vinyl)stannane；Tributylvinylstannane;Vinyltributylstannane | 7486-35-3 | C14H30Sn | 详情 | 详情 |
| (XIII) | 69066 | 2-benzyl-4-vinylisoindoline | C17H17N | 详情 | 详情 | |
| (XIV) | 69067 | 4-vinylisoindoline | C10H11N | 详情 | 详情 | |
| (XV) | 15780 | 1-(tert-butyl) 2-methyl (2S,4S)-4-hydroxytetrahydro-1H-pyrrole-1,2-dicarboxylate;(2S,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate | C11H19NO5 | 详情 | 详情 | |
| (XVI) | 69070 | (2S,4S)-1-tert-butyl 2-methyl 4-((4-vinylisoindoline-2-carbonyl)oxy)pyrrolidine-1,2-dicarboxylate | C22H28N2O6 | 详情 | 详情 | |
| (XVII) | 69068 | 4-bromoisoindoline hydrochloride;3-Bromo-1H-isoindoline Hydrochloride;4-Bromo-1H-isoindoline hydrochloride;4-Bromo-2,3-dihydro-1H-isoindole hydrochloride | 923590-95-8 | C8H8BrN.HCl | 详情 | 详情 |
| (XVIII) | 69071 | (2S,4S)-1-tert-butyl 2-methyl 4-((4-bromoisoindoline-2-carbonyl)oxy)pyrrolidine-1,2-dicarboxylate | C20H25BrN2O6 | 详情 | 详情 | |
| (XIX) | 69072 | potassium vinyltrifluoroborate;potassium trifluoro(vinyl)borate | C2H3BF3K | 详情 | 详情 | |
| (XX) | 69069 | (3S,5S)-5-(methoxycarbonyl)pyrrolidin-3-yl 4-vinylisoindoline-2-carboxylate hydrochloride | C17H20N2O4.HCl | 详情 | 详情 | |
| (XXI) | 69073 | 2-((((2,2-dimethylhex-5-en-1-yl)oxy)carbonyl)amino)-3,3-dimethylbutanoic acid | C15H27NO4 | 详情 | 详情 | |
| (XXII) | 28650 | ethyl 2-methylpropanoate；ethyl isobutyrate | 97-62-1 | C6H12O2 | 详情 | 详情 |
| (XXIII) | 11720 | 4-Bromo-1-butene | 5162-44-7 | C4H7Br | 详情 | 详情 |
| (XXIV) | 69074 | 2,2-dimethyl-5-hexen-1-ol | C8H16O | 详情 | 详情 | |
| (XXV) | 69075 | (S)-2-amino-3,3-dimethylbutanoic acid;L-tert-leucine;L-2-Amino-3,3-dimethylbutanoic acid | 20859-02-3 | C6H13NO2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XII)The reaction of protected pyrrolidone (VIII) with LHMDS and CO2 affords the corresponding pyrrolidonecarboxylic acid (IX), which is reduced at the ketonic oxygen with NaBH4 providing the hydroxyacid (X). The condensation of the previously obtained amino acid (VII) with the acid (X) by means of oxalyl chloride and triethylamine affords amide (XI), which is condensed with vinyltributylstannane (XII) by means of Pd(PPh3)4 to give the butaiene derivative (XIII). The spontaneous Diels-Alder cyclization of (XIII) yields the tricyclic compound (XIV), which is oxidized with CrO3 to the dione (XV). The deprotection of the hydroxyl groups of (XV), their reaction with oxalyl chloride and with methylenetriphenylphosphorane provides compound (XVI) with two terminal reactive double bonds. The reduction of (XVI) with DIBAL, followed by oxidation with Dess Martin periodinane (DMP) affords the corresponding aldehyde (XVII).
| 【1】 Martin, S.F.; et al.; Enantioselective total synthesis of ircinal A and related manzamine alkaloids. J Am Chem Soc 1999, 121, 4, 866. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 27301 | methylene(triphenyl)phosphorane | C19H17P | 详情 | 详情 | ||
| (VII) | 24915 | methyl (Z)-2-bromo-5-[(5-[[tert-butyl(diphenyl)silyl]oxy]pentyl)amino]-2-pentenoate | C27H38BrNO3Si | 详情 | 详情 | |
| (VIII) | 24916 | tert-butyl (2R)-2-([[tert-butyl(diphenyl)silyl]oxy]methyl)-5-oxo-1-pyrrolidinecarboxylate | C26H35NO4Si | 详情 | 详情 | |
| (IX) | 24917 | (5R)-1-(tert-butoxycarbonyl)-5-([[tert-butyl(diphenyl)silyl]oxy]methyl)-2-oxo-3-pyrrolidinecarboxylate | C27H34NO6Si | 详情 | 详情 | |
| (X) | 24918 | (5R)-1-(tert-butoxycarbonyl)-5-([[tert-butyl(diphenyl)silyl]oxy]methyl)-2-hydroxy-3-pyrrolidinecarboxylate | C27H36NO6Si | 详情 | 详情 | |
| (XI) | 24919 | tert-butyl (2R)-4-[[[(E)-4-bromo-5-methoxy-5-oxo-3-pentenyl](5-[[tert-butyl(diphenyl)silyl]oxy]pentyl)amino]carbonyl]-2-([[tert-butyl(diphenyl)silyl]oxy]methyl)-2,3-dihydro-1H-pyrrole-1-carboxylate | C54H71BrN2O7Si2 | 详情 | 详情 | |
| (XII) | 24920 | tributyl(vinyl)stannane；Tributylvinylstannane;Vinyltributylstannane | 7486-35-3 | C14H30Sn | 详情 | 详情 |
| (XIII) | 24921 | tert-butyl (2R)-2-([[tert-butyl(diphenyl)silyl]oxy]methyl)-4-([(5-[[tert-butyl(diphenyl)silyl]oxy]pentyl)[(3Z)-4-(methoxycarbonyl)-3,5-hexadienyl]amino]carbonyl)-2,3-dihydro-1H-pyrrole-1-carboxylate | C56H74N2O7Si2 | 详情 | 详情 | |
| (XIV) | 24922 | 1-(tert-butyl) 8-methyl (2R,3aS,7aR,10aS)-2-([[tert-butyl(diphenyl)silyl]oxy]methyl)-5-(5-[[tert-butyl(diphenyl)silyl]oxy]pentyl)-4-oxo-2,3,5,6,7,7a,10,10a-octahydropyrrolo[2,3-i]isoquinoline-1,8(4H)-dicarboxylate | C56H74N2O7Si2 | 详情 | 详情 | |
| (XV) | 24923 | 1-(tert-butyl) 8-methyl (2R,3aS,7aR,10aR)-2-([[tert-butyl(diphenyl)silyl]oxy]methyl)-5-(5-[[tert-butyl(diphenyl)silyl]oxy]pentyl)-4,10-dioxo-2,3,5,6,7,7a,10,10a-octahydropyrrolo[2,3-i]isoquinoline-1,8(4H)-dicarboxylate | C56H72N2O8Si2 | 详情 | 详情 | |
| (XVI) | 24924 | 1-(tert-butyl) 8-methyl (2R,3aS,7aR,10aR)-5-(5-hexenyl)-4,10-dioxo-2-vinyl-2,3,5,6,7,7a,10,10a-octahydropyrrolo[2,3-i]isoquinoline-1,8(4H)-dicarboxylate | C26H36N2O6 | 详情 | 详情 | |
| (XVII) | 24925 | tert-butyl (2R,3aR,7aR,10aR)-8-formyl-5-(5-hexenyl)-10-oxo-2-vinyl-2,3,5,6,7,7a,10,10a-octahydropyrrolo[2,3-i]isoquinoline-1(4H)-carboxylate | C25H36N2O4 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：Diels-Alder condensation of benzopyran (I) with methyl (trimethylsilyl)propynoate (II) gave rise to tetrahydronaphthalene (III). After reduction of the ester group of (III) with LiAlH4, the resulting alcohol (IV) was further oxidized to aldehyde (V) by means of 4-benzylpyridinium dichromate. Treatment of (V) with iodine monochloride produced iodonaphthalene (VI). Subsequent reaction of (VI) with vinyl tributyltin and palladium tetrakis(triphenylphosphine) yielded the vinyl naphthalene (VII). Wittig reaction of (VIII with (carbomethoxymethylidene)triphenylphosphorane (VIII) gave the arylpropenoate ester (IX), which was reduced to the saturated ester (X) employing samarium iodide.
| 【1】 Lavielle, G.; Cimetiere, B.; Verbeuren, T.; Simonet, S.; Descombes, J.-J. (ADIR et Cie.); Nouveaux dérivés de benzènsessulfonylamine, leur procédé depréparation et les compositions pharmaceutiques qui les contiennent. EP 0864561 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 24920 | tributyl(vinyl)stannane；Tributylvinylstannane;Vinyltributylstannane | 7486-35-3 | C14H30Sn | 详情 | 详情 | |
| (I) | 19586 | 4-chloro-N-(2-oxo-5,6,7,8-tetrahydro-2H-chromen-6-yl)benzenesulfonamide | C15H14ClNO4S | 详情 | 详情 | |
| (II) | 32594 | methyl 3-(trimethylsilyl)-2-propynoate | C7H12O2Si | 详情 | 详情 | |
| (III) | 32595 | methyl 6-[[(4-chlorophenyl)sulfonyl]amino]-2-(trimethylsilyl)-5,6,7,8-tetrahydro-1-naphthalenecarboxylate | C21H26ClNO4SSi | 详情 | 详情 | |
| (IV) | 32596 | 4-chloro-N-[5-(hydroxymethyl)-6-(trimethylsilyl)-1,2,3,4-tetrahydro-2-naphthalenyl]benzenesulfonamide | C20H26ClNO3SSi | 详情 | 详情 | |
| (V) | 32597 | 4-chloro-N-[5-formyl-6-(trimethylsilyl)-1,2,3,4-tetrahydro-2-naphthalenyl]benzenesulfonamide | C20H24ClNO3SSi | 详情 | 详情 | |
| (VI) | 19571 | 4-chloro-N-(5-formyl-6-iodo-1,2,3,4-tetrahydro-2-naphthalenyl)benzenesulfonamide | C17H15ClINO3S | 详情 | 详情 | |
| (VII) | 32598 | 4-chloro-N-(5-formyl-6-vinyl-1,2,3,4-tetrahydro-2-naphthalenyl)benzenesulfonamide | C19H18ClNO3S | 详情 | 详情 | |
| (VIII) | 14689 | Methyl (triphenylphosphoranylidene)acetate; (methoxycarbonylmethylene)triphenylphosphorane；Methyl 2-(triphenyl-lambda(5)-phosphanylidene)acetate | 2605-67-6 | C21H19O2P | 详情 | 详情 |
| (IX) | 32599 | methyl (E)-3-(6-[[(4-chlorophenyl)sulfonyl]amino]-2-vinyl-5,6,7,8-tetrahydro-1-naphthalenyl)-2-propenoate | C22H22ClNO4S | 详情 | 详情 | |
| (X) | 32600 | methyl 3-(6-[[(4-chlorophenyl)sulfonyl]amino]-2-vinyl-5,6,7,8-tetrahydro-1-naphthalenyl)propanoate | C22H24ClNO4S | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：The bromination of 1,6-naphthyridine-2-carboxylic acid (I) with Br2 in acetic acid gives the 8-bromo derivative (II), which is condensed with 2-isopropoxybenzylamine (III) by means of EDC and HOBT in DMF yielding the corresponding amide (IV). Finally, this compound is vinylated with CH2 = CH-SnBu3 and PdCl2(PPh3)2 in DMF.
| 【1】 May, S.; Stefanac, T.; Jin, H.; Wang, W.; Yuen, L.; Falardeau, G.; Lavallee, J.-F.; Bedard, J.; Chan, L.; Discovery of 1,6-naphthyridines as a novel class of potent and selective human cytomegalovirus inhibitors. J Med Chem 1999, 42, 16, 3023. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 24920 | tributyl(vinyl)stannane；Tributylvinylstannane;Vinyltributylstannane | 7486-35-3 | C14H30Sn | 详情 | 详情 | |
| (I) | 37221 | [1,6]naphthyridine-2-carboxylic acid | C9H6N2O2 | 详情 | 详情 | |
| (II) | 37223 | 8-bromo[1,6]naphthyridine-2-carboxylic acid | C9H5BrN2O2 | 详情 | 详情 | |
| (III) | 37222 | (2-isopropoxyphenyl)methanamine; 2-isopropoxybenzylamine | C10H15NO | 详情 | 详情 | |
| (IV) | 37224 | 8-bromo-N-(2-isopropoxybenzyl)[1,6]naphthyridine-2-carboxamide | C19H18BrN3O2 | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(IV)Silylation of 5-iodocytosine (I) with hexamethyldisilazane, followed by condensation with 5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranoside (II) in the presence of stannic chloride provided 2',3'-di-O-acetyl-5'-deoxy-5-iodocytidine (III). The title vinylcytidine derivative was then obtained by displacement of the iodine atom of (III) with tri-n-butyl(vinyl)stannane (IV) using palladium catalyst and trifurylphosphine.
| 【1】 Hattori, K.; Suda, H.; Ishikawa, T.; Shimma, N.; Kohchi, Y.; Oikawa, N.; Ishitsuka, H. (F. Hoffmann-La Roche AG); 5'-Deoxy-cytidine derivs.. DE 19823484; EP 0882734; ES 2142763; FR 2763953; GB 2325931; JP 1998330395 . |
| 【2】 Ishitsuka, H.; Kohchi, Y.; Shimma, N.; Oikawa, N.; Hattori, K.; Suda, H.; Ishikawa, T. (F. Hoffmann-La Roche AG); 5'-Deoxycytidine derivs.. EP 1060183; WO 9940099 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 44976 | 4-amino-5-iodo-2(1H)-pyrimidinone; 5-Iodocytosine | 1122-44-7 | C4H4IN3O | 详情 | 详情 |
| (II) | 44978 | (2R,3R,4R)-4,5-bis(acetoxy)-2-methyltetrahydro-3-furanyl acetate | C11H16O7 | 详情 | 详情 | |
| (III) | 44977 | (2R,3R,4R,5R)-4-(acetoxy)-2-[4-amino-5-iodo-2-oxo-1(2H)-pyrimidinyl]-5-methyltetrahydro-3-furanyl acetate | C13H16IN3O6 | 详情 | 详情 | |
| (IV) | 24920 | tributyl(vinyl)stannane；Tributylvinylstannane;Vinyltributylstannane | 7486-35-3 | C14H30Sn | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(X)Heck reaction of aryl bromide (IX) with vinyl tributyltin (X) in the presence of palladium catalyst gave the vinyl tetrahydronaphthalene (XI), which was converted to the primary alcohol (XII) by means of hydroboration with borane in THF followed by oxidative treatment with H2O2 and NaOH. Reaction of alcohol (XII) with p-toluenesulfonyl chloride and Et3N produced the corresponding tosylate (XIII) (1). This was then condensed with 6-fluoro-3-(4-piperidinyl)benzisoxazole (XIV), yielding adduct (XV). Finally, basic hydrolysis of the ester group of (XIV) provided the title carboxylic acid.
| 【1】 Cimetiere, B.; et al.; Discovery of new combined 5-HT2 and TP-receptor antagonists. 222nd ACS Natl Meet (Aug 26 2001, Chicago) 2001, Abst MEDI 57. |
| 【2】 Verbeuren, T.; Simonet, S.; Descombes, J.-J.; Cimetiere, B.; Lavielle, G. (ADIR et Cie.); Benzenesulfonamide derivs., process for their preparation and pharmaceutical compsns. containing them. EP 1118610; FR 2803848; JP 2001226353 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 49923 | methyl 3-(3-bromo-6-[[(4-chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-1-naphthalenyl)propanoate | C20H21BrClNO4S | 详情 | 详情 | |
| (X) | 24920 | tributyl(vinyl)stannane；Tributylvinylstannane;Vinyltributylstannane | 7486-35-3 | C14H30Sn | 详情 | 详情 |
| (XI) | 49924 | methyl 3-(6-[[(4-chlorophenyl)sulfonyl]amino]-3-vinyl-5,6,7,8-tetrahydro-1-naphthalenyl)propanoate | C22H24ClNO4S | 详情 | 详情 | |
| (XII) | 49925 | methyl 3-(6-[[(4-chlorophenyl)sulfonyl]amino]-3-formyl-5,6,7,8-tetrahydro-1-naphthalenyl)propanoate | C21H22ClNO5S | 详情 | 详情 | |
| (XIII) | 49926 | methyl 3-[6-[[(4-chlorophenyl)sulfonyl]amino]-3-(hydroxymethyl)-5,6,7,8-tetrahydro-1-naphthalenyl]propanoate | C21H24ClNO5S | 详情 | 详情 | |
| (XIV) | 17910 | 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole | C12H13FN2O | 详情 | 详情 | |
| (XV) | 49964 | methyl 3-(6-[[(4-chlorophenyl)sulfonyl]amino]-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-5,6,7,8-tetrahydro-1-naphthalenyl)propanoate | C34H37ClFN3O5S | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(X)Heck reaction of aryl bromide (IX) with vinyl tributyltin (X) in the presence of palladium catalyst gave the vinyl tetrahydronaphthalene (XI), which was subjected to oxidative double-bond cleavage to aldehyde (XII) using NaIO4 in the presence of a catalytic amount of OsO4. Aldehyde reduction with NaBH4 provided alcohol (XIII). This was then converted to the corresponding bromide (XIV) by treatment with carbon tetrabromide and triphenylphosphine.
| 【1】 Cimetiere, B.; et al.; Discovery of new combined 5-HT2 and TP-receptor antagonists. 222nd ACS Natl Meet (Aug 26 2001, Chicago) 2001, Abst MEDI 57. |
| 【2】 Verbeuren, T.; Simonet, S.; Descombes, J.-J.; Cimetiere, B.; Lavielle, G. (ADIR et Cie.); Benzenesulfonamide derivs., process for their preparation and pharmaceutical compsns. containing them. EP 1118610; FR 2803848; JP 2001226353 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 49923 | methyl 3-(3-bromo-6-[[(4-chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-1-naphthalenyl)propanoate | C20H21BrClNO4S | 详情 | 详情 | |
| (X) | 24920 | tributyl(vinyl)stannane；Tributylvinylstannane;Vinyltributylstannane | 7486-35-3 | C14H30Sn | 详情 | 详情 |
| (XI) | 49924 | methyl 3-(6-[[(4-chlorophenyl)sulfonyl]amino]-3-vinyl-5,6,7,8-tetrahydro-1-naphthalenyl)propanoate | C22H24ClNO4S | 详情 | 详情 | |
| (XII) | 49925 | methyl 3-(6-[[(4-chlorophenyl)sulfonyl]amino]-3-formyl-5,6,7,8-tetrahydro-1-naphthalenyl)propanoate | C21H22ClNO5S | 详情 | 详情 | |
| (XIII) | 49926 | methyl 3-[6-[[(4-chlorophenyl)sulfonyl]amino]-3-(hydroxymethyl)-5,6,7,8-tetrahydro-1-naphthalenyl]propanoate | C21H24ClNO5S | 详情 | 详情 | |
| (XIV) | 49927 | methyl 3-(3-(bromomethyl)-6-[[(4-chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-1-naphthalenyl)propanoate | C21H23BrClNO4S | 详情 | 详情 |