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【结 构 式】 
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【药物名称】Ro-0094889, Ro-09-4889 【化学名称】2',3'-Di-O-acetyl-5'-deoxy-5-vinylcytidine 【CA登记号】216449-60-4 【 分 子 式 】C15H19N3O6 【 分 子 量 】337.33518 |
【开发单位】Chugai (Originator) 【药理作用】Chemical Delivery Systems, DRUG DELIVERY, Drug Delivery Systems, Inhibitors of the Degradation of Anticancer Drugs, Modulators of the Therapeutic Activity of Antineoplastic Agents, ONCOLYTIC DRUGS |
合成路线1
Silylation of 5-iodocytosine (I) with hexamethyldisilazane, followed by condensation with 5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranoside (II) in the presence of stannic chloride provided 2',3'-di-O-acetyl-5'-deoxy-5-iodocytidine (III). The title vinylcytidine derivative was then obtained by displacement of the iodine atom of (III) with tri-n-butyl(vinyl)stannane (IV) using palladium catalyst and trifurylphosphine.
| 【1】 Hattori, K.; Suda, H.; Ishikawa, T.; Shimma, N.; Kohchi, Y.; Oikawa, N.; Ishitsuka, H. (F. Hoffmann-La Roche AG); 5'-Deoxy-cytidine derivs.. DE 19823484; EP 0882734; ES 2142763; FR 2763953; GB 2325931; JP 1998330395 . |
| 【2】 Ishitsuka, H.; Kohchi, Y.; Shimma, N.; Oikawa, N.; Hattori, K.; Suda, H.; Ishikawa, T. (F. Hoffmann-La Roche AG); 5'-Deoxycytidine derivs.. EP 1060183; WO 9940099 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 44976 | 4-amino-5-iodo-2(1H)-pyrimidinone; 5-Iodocytosine | 1122-44-7 | C4H4IN3O | 详情 | 详情 |
| (II) | 44978 | (2R,3R,4R)-4,5-bis(acetoxy)-2-methyltetrahydro-3-furanyl acetate | C11H16O7 | 详情 | 详情 | |
| (III) | 44977 | (2R,3R,4R,5R)-4-(acetoxy)-2-[4-amino-5-iodo-2-oxo-1(2H)-pyrimidinyl]-5-methyltetrahydro-3-furanyl acetate | C13H16IN3O6 | 详情 | 详情 | |
| (IV) | 24920 | tributyl(vinyl)stannane；Tributylvinylstannane;Vinyltributylstannane | 7486-35-3 | C14H30Sn | 详情 | 详情 |