2-Mercaptopyrimidine; 2-Pyrimidinethiol -Drug Synthesis Database

【结构式】

【分子编号】24573

【品名】2-Mercaptopyrimidine; 2-Pyrimidinethiol

【CA登记号】1450-85-7

【分子式】C₄H₄N₂S

【分子量】112.15524

【元素组成】C 42.84% H 3.59% N 24.98% S 28.59%

与该中间体有关的原料药合成路线共 2 条

该中间体在本合成路线中的序号：(II)

By condensation of 3-(chloromethyl)pyridine (I) with 2-mercaptopyrimidine (II) in ethanol-water at room temperature.

【1】 Engler, H.; Schickaneder, H.; Szelenyi, I. (Heumann Pharma GmbH & Co.); Imidazoyl-substd. thiomethylpyridine derivs., method of administration thereof and medicaments containing them. DE 3216843; EP 0093252; US 4810715 .
【2】 Castaner, J.; Prous, J.; Tasuldine. Drugs Fut 1986, 11, 5, 397.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	15793	3-(Chloromethyl)pyridine	3099-31-8	C₆H₆ClN	详情	详情
(II)	24573	2-Mercaptopyrimidine; 2-Pyrimidinethiol	1450-85-7	C₄H₄N₂S	详情	详情

该中间体在本合成路线中的序号：(II)

The title compound was prepared by condensation of chloro derivative (I) with 2-mercaptopyrimidine (II) in the presence of DBU in THF.

【1】 Freyne, E.J.E.; Lacrampe, J.F.A.; Boeckx, G.M.; Venet, M.G. (Janssen Pharmaceutica NV); IL-5 inhibiting 6-azauracil derivs.. EP 1000040; WO 9902505 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	30779	2-[3,5-dichloro-4-[chloro(4-chlorophenyl)methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione		C₁₆H₉Cl₄N₃O₂	详情	详情
(II)	24573	2-Mercaptopyrimidine; 2-Pyrimidinethiol	1450-85-7	C₄H₄N₂S	详情	详情

Extended Information