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【结 构 式】 
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【药物名称】Tasuldine, HE-10004 【化学名称】2-(Pyridin-3-ylmethylsulfanyl)pyrimidine 【CA登记号】88579-39-9 【 分 子 式 】C10H9N3S 【 分 子 量 】203.26733 |
【开发单位】Heumann (Originator) 【药理作用】Mucolytics, RESPIRATORY DRUGS, Treatment of Upper Respiratory Tract Disorders |
合成路线1
By condensation of 3-(chloromethyl)pyridine (I) with 2-mercaptopyrimidine (II) in ethanol-water at room temperature.
| 【1】 Engler, H.; Schickaneder, H.; Szelenyi, I. (Heumann Pharma GmbH & Co.); Imidazoyl-substd. thiomethylpyridine derivs., method of administration thereof and medicaments containing them. DE 3216843; EP 0093252; US 4810715 . |
| 【2】 Castaner, J.; Prous, J.; Tasuldine. Drugs Fut 1986, 11, 5, 397. |
Extended Information