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【结 构 式】 
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【药物名称】R-146225 【化学名称】(-)-2-[3,5-Dichloro-4-[1-(4-chlorophenyl)-1-(2-pyrimidinylsulfanyl)methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione 【CA登记号】219979-42-7 【 分 子 式 】C20H12Cl3N5O2S 【 分 子 量 】492.77394 |
【开发单位】Janssen (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, Drugs for Allergic Rhinitis, RESPIRATORY DRUGS, Treatment of Upper Respiratory Tract Disorders, IL-5 Production Inhibitors |
合成路线1
The title compound was prepared by condensation of chloro derivative (I) with 2-mercaptopyrimidine (II) in the presence of DBU in THF.
| 【1】 Freyne, E.J.E.; Lacrampe, J.F.A.; Boeckx, G.M.; Venet, M.G. (Janssen Pharmaceutica NV); IL-5 inhibiting 6-azauracil derivs.. EP 1000040; WO 9902505 . |
Extended Information