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【结 构 式】 
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【分子编号】24489 【品名】2-(heptyloxy)phenylformamide 【CA登记号】 |
【 分 子 式 】C14H21NO2 【 分 子 量 】235.32628 【元素组成】C 71.46% H 8.99% N 5.95% O 13.6% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)Reaction of 1,2-epoxypropane (I) and diethyl amine (II) yields 1-diethylamino-2-propanol (III). 2-Heptyloxyaniline (IV) is reacted with a solution of phosgene in toluene to give 2-heptyloxyphenyliso cyanate (V), which is treated with the aminoalcohol (III) to give title compound.
| 【1】 Hartl, J.; Benes, L.; Kopacova, L.; Borovansky, A.; Basic isopropyl esters of alkoxy-subsituted carbanilics acids. Local anesthetics. XLIII. Acta Fac Pharm Univ Comeniana 1973, 23, 2, 81. |
| 【2】 Benes, L.; et al.; Studies on local anesthetics. LXV. Basic esters of o-alkoxycarbanilic acids with local-anesthetic and anti-arrhythmic effects. Cesk Farm 1978, 27, 4, 167. |
| 【3】 Radi, S.; Carbizocaine hydrochloride. Drugs Fut 1986, 11, 7, 555. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24485 | Propylene oxide; 2-Methyloxirane | C3H6O | 详情 | 详情 | |
| (II) | 24486 | Diethylamine; N,N-Diethylamine | 109-89-7 | C4H11N | 详情 | 详情 |
| (III) | 24487 | 1-(diethylamino)-2-propanol | 4402-32-8 | C7H17NO | 详情 | 详情 |
| (IV) | 24488 | 2-(heptyloxy)aniline | C13H21NO | 详情 | 详情 | |
| (V) | 24489 | 2-(heptyloxy)phenylformamide | C14H21NO2 | 详情 | 详情 |
Extended Information