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【结 构 式】 
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【药物名称】Carbisocaine hydrochloride, Carbizocaine hydrochloride, BK 95 【化学名称】N-(2-Heptyloxyphenyl)carbamic acid 2-(diethylamino)-1-methylethyl ester hydrochloride 【CA登记号】68931-03-3, 76629-87-3 (free base) 【 分 子 式 】C21H37ClN2O3 【 分 子 量 】400.99364 |
【开发单位】Res. Inst. Pharmacy Biochemistry (VUFB) (Originator), Slovak Acad. Sci. (Originator), Univ. Komenskeho, Bratislava (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Anesthetic Drugs, Local Anesthetics |
合成路线1
Reaction of 1,2-epoxypropane (I) and diethyl amine (II) yields 1-diethylamino-2-propanol (III). 2-Heptyloxyaniline (IV) is reacted with a solution of phosgene in toluene to give 2-heptyloxyphenyliso cyanate (V), which is treated with the aminoalcohol (III) to give title compound.
| 【1】 Hartl, J.; Benes, L.; Kopacova, L.; Borovansky, A.; Basic isopropyl esters of alkoxy-subsituted carbanilics acids. Local anesthetics. XLIII. Acta Fac Pharm Univ Comeniana 1973, 23, 2, 81. |
| 【2】 Benes, L.; et al.; Studies on local anesthetics. LXV. Basic esters of o-alkoxycarbanilic acids with local-anesthetic and anti-arrhythmic effects. Cesk Farm 1978, 27, 4, 167. |
| 【3】 Radi, S.; Carbizocaine hydrochloride. Drugs Fut 1986, 11, 7, 555. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24485 | Propylene oxide; 2-Methyloxirane | C3H6O | 详情 | 详情 | |
| (II) | 24486 | Diethylamine; N,N-Diethylamine | 109-89-7 | C4H11N | 详情 | 详情 |
| (III) | 24487 | 1-(diethylamino)-2-propanol | 4402-32-8 | C7H17NO | 详情 | 详情 |
| (IV) | 24488 | 2-(heptyloxy)aniline | C13H21NO | 详情 | 详情 | |
| (V) | 24489 | 2-(heptyloxy)phenylformamide | C14H21NO2 | 详情 | 详情 |
Extended Information