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【结 构 式】

【分子编号】24488

【品名】2-(heptyloxy)aniline

【CA登记号】

【 分 子 式 】C13H21NO

【 分 子 量 】207.31588

【元素组成】C 75.32% H 10.21% N 6.76% O 7.72%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Reaction of 1,2-epoxypropane (I) and diethyl amine (II) yields 1-diethylamino-2-propanol (III). 2-Heptyloxyaniline (IV) is reacted with a solution of phosgene in toluene to give 2-heptyloxyphenyliso cyanate (V), which is treated with the aminoalcohol (III) to give title compound.

1 Hartl, J.; Benes, L.; Kopacova, L.; Borovansky, A.; Basic isopropyl esters of alkoxy-subsituted carbanilics acids. Local anesthetics. XLIII. Acta Fac Pharm Univ Comeniana 1973, 23, 2, 81.
2 Benes, L.; et al.; Studies on local anesthetics. LXV. Basic esters of o-alkoxycarbanilic acids with local-anesthetic and anti-arrhythmic effects. Cesk Farm 1978, 27, 4, 167.
3 Radi, S.; Carbizocaine hydrochloride. Drugs Fut 1986, 11, 7, 555.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 24485 Propylene oxide; 2-Methyloxirane C3H6O 详情 详情
(II) 24486 Diethylamine; N,N-Diethylamine 109-89-7 C4H11N 详情 详情
(III) 24487 1-(diethylamino)-2-propanol 4402-32-8 C7H17NO 详情 详情
(IV) 24488 2-(heptyloxy)aniline C13H21NO 详情 详情
(V) 24489 2-(heptyloxy)phenylformamide C14H21NO2 详情 详情
Extended Information