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【结 构 式】 
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【分子编号】24290 【品名】2-(3-benzoylphenyl)propionic acid 【CA登记号】22071-15-4 |
【 分 子 式 】C16H14O3 【 分 子 量 】254.28536 【元素组成】C 75.57% H 5.55% O 18.88% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(I)The reaction of 2-(3-benzoylphenyl)propionic acid (I) with SOCl2 or PCl3 gives the corresponding acyl chloride (II), which is then condensed with 4-methylpyridine-2-amine (III) by means of 4-methylpyridine in pyridine.
| 【1】 Vega, A.; Prieto, J.; Moragues, J. (Fordonal SL); Procedimiento para la preparacion de una amida de la 2-amino-4-metylpiridina. BE 0882711; ES 8102556; IT 1130573 . |
| 【2】 Vega Noverola, A.; Prieto Soto, J.; Spickett, R.G.W.; Amide derivs. of 3-benzoyl-phenylalkanoic acids. GB 1436502 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 31150 | 4-methylpyridine | 108-89-4 | C6H7N | 详情 | 详情 |
| (I) | 24290 | 2-(3-benzoylphenyl)propionic acid | 22071-15-4 | C16H14O3 | 详情 | 详情 |
| (II) | 24291 | 2-(3-benzoylphenyl)propanoyl chloride | C16H13ClO2 | 详情 | 详情 | |
| (III) | 14614 | 2-Amino-4-picoline; 4-Methyl-2-pyridinamine; 4-Methyl-2-pyridinylamine; 2-Amino-4-methylpyridine | 695-34-1 | C6H8N2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(I)By chlorination of acid (I) and subsequent esterification with the aminoalcohol (II).
| 【1】 Milani, C.; Carminati, G.M.; Sovera, A. (3M Pharmaceuticals); A chlorobenzhydryl piperazine derivative. DE 2950378 . |
| 【2】 Prous, J.; Castaner, J.; Fenclozine maleate. Drugs Fut 1986, 11, 8, 650. |
Extended Information