【结 构 式】 |
【药物名称】Piketoprofen, Calmatel 【化学名称】m-Benzoyl-N-(4-methyl-2-pyridyl)hydratropamide 【CA登记号】60576-13-8 【 分 子 式 】C22H20N2O2 【 分 子 量 】344.4169 |
【开发单位】Almirall Prodesfarma (Originator), Italfarmaco (Licensee) 【药理作用】Antiarthritic Drugs, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Non-Steroidal Antiinflammatory Drugs |
合成路线1
The reaction of 2-(3-benzoylphenyl)propionic acid (I) with SOCl2 or PCl3 gives the corresponding acyl chloride (II), which is then condensed with 4-methylpyridine-2-amine (III) by means of 4-methylpyridine in pyridine.
【1】 Vega, A.; Prieto, J.; Moragues, J. (Fordonal SL); Procedimiento para la preparacion de una amida de la 2-amino-4-metylpiridina. BE 0882711; ES 8102556; IT 1130573 . |
【2】 Vega Noverola, A.; Prieto Soto, J.; Spickett, R.G.W.; Amide derivs. of 3-benzoyl-phenylalkanoic acids. GB 1436502 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(A) | 31150 | 4-methylpyridine | 108-89-4 | C6H7N | 详情 | 详情 |
(I) | 24290 | 2-(3-benzoylphenyl)propionic acid | 22071-15-4 | C16H14O3 | 详情 | 详情 |
(II) | 24291 | 2-(3-benzoylphenyl)propanoyl chloride | C16H13ClO2 | 详情 | 详情 | |
(III) | 14614 | 2-Amino-4-picoline; 4-Methyl-2-pyridinamine; 4-Methyl-2-pyridinylamine; 2-Amino-4-methylpyridine | 695-34-1 | C6H8N2 | 详情 | 详情 |
Extended Information