Fenclozine maleate, S 1429, -Drug Synthesis Database

【结构式】

【药物名称】Fenclozine maleate, S 1429

【化学名称】2-[2-[4-(4-Chlorobenzhydryl)piperazino]ethoxy]eth yl 2-(3-benzoylphenyl)propionate dimaleate

【CA登记号】76823-82-0

【分子式】C₄₅H₄₇ClN₂O₁₂

【分子量】843.33554

【开发单位】3M Pharmaceuticals (Originator), Edmond Pharma (Licensee)

【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Non-Opioid Analgesics, Histamine H1 Antagonists, Non-Steroidal Antiinflammatory Drugs

合成路线1

By chlorination of acid (I) and subsequent esterification with the aminoalcohol (II).

【1】 Milani, C.; Carminati, G.M.; Sovera, A. (3M Pharmaceuticals); A chlorobenzhydryl piperazine derivative. DE 2950378 .
【2】 Prous, J.; Castaner, J.; Fenclozine maleate. Drugs Fut 1986, 11, 8, 650.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	24291	2-(3-benzoylphenyl)propanoyl chloride		C₁₆H₁₃ClO₂	详情	详情
(I)	24290	2-(3-benzoylphenyl)propionic acid	22071-15-4	C₁₆H₁₄O₃	详情	详情
(II)	24292	2-(2-[4-[(4-chlorophenyl)(phenyl)methyl]-1-piperazinyl]ethoxy)-1-ethanol		C₂₁H₂₇ClN₂O₂	详情	详情

Extended Information