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【结 构 式】 
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【分子编号】24141 【品名】N-(10,11-dithia-7,14,21-triazadocos-1-yl)-N-methylamine 【CA登记号】 |
【 分 子 式 】C18H42N4S2 【 分 子 量 】378.69044 【元素组成】C 57.09% H 11.18% N 14.79% S 16.94% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)N1,N1'-Dithiobis(ethane-2,1-diyl)bis(hexane-1,6-diamine) (II) is prepared starting from 6-aminohexylcyste amine (I) by potassium ferricyanide oxidation. The condensation of (II) with pyrrol 2-carboxaldehyde and subsequent reduction with NaHB4 of the resulting Schitf base gives (III), which is crvstallized as tetraoxatate.
| 【1】 Angeli, P.; et al.; Structure-activity relationships among benextramine-related tetraamine disulfides at peripheral alpha-adrenoreceptors. J Med Chem 1985, 28, 11, 1643. |
| 【2】 Brasili, L.; Pyrextramine. Drugs Fut 1986, 11, 1, 32. |
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