2-[[6-(methylamino)hexyl]amino]-1-ethanethiol -Drug Synthesis Database

【结构式】

【分子编号】24140

【品名】2-[[6-(methylamino)hexyl]amino]-1-ethanethiol

【CA登记号】

【分子式】C₉H₂₂N₂S

【分子量】190.35316

【元素组成】C 56.79% H 11.65% N 14.72% S 16.85%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

N1,N1'-Dithiobis(ethane-2,1-diyl)bis(hexane-1,6-diamine) (II) is prepared starting from 6-aminohexylcyste amine (I) by potassium ferricyanide oxidation. The condensation of (II) with pyrrol 2-carboxaldehyde and subsequent reduction with NaHB4 of the resulting Schitf base gives (III), which is crvstallized as tetraoxatate.

参考文献中间体

合成目标

【1】 Angeli, P.; et al.; Structure-activity relationships among benextramine-related tetraamine disulfides at peripheral alpha-adrenoreceptors. J Med Chem 1985, 28, 11, 1643.
【2】 Brasili, L.; Pyrextramine. Drugs Fut 1986, 11, 1, 32.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	21081	Pyrrole-2-carbaldehyde; 1H-pyrrole-2-carbaldehyde	1003-29-8	C₅H₅NO	详情	详情
(I)	24140	2-[[6-(methylamino)hexyl]amino]-1-ethanethiol		C₉H₂₂N₂S	详情	详情
(II)	24141	N-(10,11-dithia-7,14,21-triazadocos-1-yl)-N-methylamine		C₁₈H₄₂N₄S₂	详情	详情

Extended Information