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【结 构 式】 
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【药物名称】Pyrextramine 【化学名称】2,2'-Dithiobis(ethane-2,1-diyl)bis(imino)bis(hexane-6,1-diyl)bis(imino)bis(methylene)bis(1H-pyrrole) tetraoxalate 【CA登记号】92588-09-5 (free base) 【 分 子 式 】C34H56N6O16S2 【 分 子 量 】868.98402 |
【开发单位】Università degli Studi di Camerino (Originator) 【药理作用】Pharmacological Tools, alpha-Adrenoceptor Antagonists |
合成路线1
N1,N1'-Dithiobis(ethane-2,1-diyl)bis(hexane-1,6-diamine) (II) is prepared starting from 6-aminohexylcyste amine (I) by potassium ferricyanide oxidation. The condensation of (II) with pyrrol 2-carboxaldehyde and subsequent reduction with NaHB4 of the resulting Schitf base gives (III), which is crvstallized as tetraoxatate.
| 【1】 Angeli, P.; et al.; Structure-activity relationships among benextramine-related tetraamine disulfides at peripheral alpha-adrenoreceptors. J Med Chem 1985, 28, 11, 1643. |
| 【2】 Brasili, L.; Pyrextramine. Drugs Fut 1986, 11, 1, 32. |
Extended Information