【结 构 式】 |
【分子编号】24064 【品名】2-(3-methoxyphenyl)-N-methyl-1-ethanamine 【CA登记号】 |
【 分 子 式 】C10H15NO 【 分 子 量 】165.23524 【元素组成】C 72.69% H 9.15% N 8.48% O 9.68% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(VI)By condensation of 2-(3-methoxyphenyl)tetradecanenitrile (I) [prepared by alkylation of 3-methoxyphenylacetonitrile (III) with 1-bromoundecane (IV) with 1-chloro-4-methyl-6-(3-methoxyphenyl)-4-azahexane (II) (prepared by alkylation of N-methyl-[2-(3-methoxyphenyl)ethylamine (VI) with 1-bromo-3-chloropropane (V)) by means of sodium amide in refluxing toluene.
【1】 Ehrmann, O.; et al. (BASF AG); omega-Cyano-1, omega-diphenyl-azaalkiane derivatives, their preparation and drugs containing them. DE 3144150 . |
【2】 Castaner, J.; Prous, J.; Anipamil. Drugs Fut 1986, 11, 3, 171. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 24059 | 2-(3-methoxyphenyl)tetradecanenitrile | C21H33NO | 详情 | 详情 | |
(II) | 24060 | 3-chloro-N-(3-methoxyphenethyl)-N-methyl-1-propanamine | C13H20ClNO | 详情 | 详情 | |
(III) | 24061 | 3-methoxyphenylacetonitrile; 2-(3-methoxyphenyl)acetonitrile | 19924-43-7 | C9H9NO | 详情 | 详情 |
(IV) | 24062 | 1-bromododecane | 143-15-7 | C12H25Br | 详情 | 详情 |
(V) | 10358 | 1-Bromo-3-chloropropane | 109-70-6 | C3H6BrCl | 详情 | 详情 |
(VI) | 24064 | 2-(3-methoxyphenyl)-N-methyl-1-ethanamine | C10H15NO | 详情 | 详情 |
Extended Information