2-(3-methoxyphenyl)tetradecanenitrile -Drug Synthesis Database

【结构式】

【分子编号】24059

【品名】2-(3-methoxyphenyl)tetradecanenitrile

【CA登记号】

【分子式】C₂₁H₃₃NO

【分子量】315.49916

【元素组成】C 79.95% H 10.54% N 4.44% O 5.07%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

By condensation of 2-(3-methoxyphenyl)tetradecanenitrile (I) [prepared by alkylation of 3-methoxyphenylacetonitrile (III) with 1-bromoundecane (IV) with 1-chloro-4-methyl-6-(3-methoxyphenyl)-4-azahexane (II) (prepared by alkylation of N-methyl-[2-(3-methoxyphenyl)ethylamine (VI) with 1-bromo-3-chloropropane (V)) by means of sodium amide in refluxing toluene.

参考文献中间体

合成目标

【1】 Ehrmann, O.; et al. (BASF AG); omega-Cyano-1, omega-diphenyl-azaalkiane derivatives, their preparation and drugs containing them. DE 3144150 .
【2】 Castaner, J.; Prous, J.; Anipamil. Drugs Fut 1986, 11, 3, 171.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	24059	2-(3-methoxyphenyl)tetradecanenitrile		C₂₁H₃₃NO	详情	详情
(II)	24060	3-chloro-N-(3-methoxyphenethyl)-N-methyl-1-propanamine		C₁₃H₂₀ClNO	详情	详情
(III)	24061	3-methoxyphenylacetonitrile; 2-(3-methoxyphenyl)acetonitrile	19924-43-7	C₉H₉NO	详情	详情
(IV)	24062	1-bromododecane	143-15-7	C₁₂H₂₅Br	详情	详情
(V)	10358	1-Bromo-3-chloropropane	109-70-6	C₃H₆BrCl	详情	详情
(VI)	24064	2-(3-methoxyphenyl)-N-methyl-1-ethanamine		C₁₀H₁₅NO	详情	详情

Extended Information