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【结 构 式】 
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【药物名称】Anipamil 【化学名称】alpha-Dodecyl-3-methoxy-alpha-[3-[N-[2-(3-methoxyphenyl)ethyl]-N-methylamino]propyl]benzeneacetonitrile 【CA登记号】83200-10-6 【 分 子 式 】C34H52N2O2 【 分 子 量 】520.80574 |
【开发单位】Abbott (Originator) 【药理作用】Angina pectoris, Treatment of, CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Calcium Channel Blockers |
合成路线1
By condensation of 2-(3-methoxyphenyl)tetradecanenitrile (I) [prepared by alkylation of 3-methoxyphenylacetonitrile (III) with 1-bromoundecane (IV) with 1-chloro-4-methyl-6-(3-methoxyphenyl)-4-azahexane (II) (prepared by alkylation of N-methyl-[2-(3-methoxyphenyl)ethylamine (VI) with 1-bromo-3-chloropropane (V)) by means of sodium amide in refluxing toluene.
| 【1】 Ehrmann, O.; et al. (BASF AG); omega-Cyano-1, omega-diphenyl-azaalkiane derivatives, their preparation and drugs containing them. DE 3144150 . |
| 【2】 Castaner, J.; Prous, J.; Anipamil. Drugs Fut 1986, 11, 3, 171. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24059 | 2-(3-methoxyphenyl)tetradecanenitrile | C21H33NO | 详情 | 详情 | |
| (II) | 24060 | 3-chloro-N-(3-methoxyphenethyl)-N-methyl-1-propanamine | C13H20ClNO | 详情 | 详情 | |
| (III) | 24061 | 3-methoxyphenylacetonitrile; 2-(3-methoxyphenyl)acetonitrile | 19924-43-7 | C9H9NO | 详情 | 详情 |
| (IV) | 24062 | 1-bromododecane | 143-15-7 | C12H25Br | 详情 | 详情 |
| (V) | 10358 | 1-Bromo-3-chloropropane | 109-70-6 | C3H6BrCl | 详情 | 详情 |
| (VI) | 24064 | 2-(3-methoxyphenyl)-N-methyl-1-ethanamine | C10H15NO | 详情 | 详情 |