1-(4-fluoro-2-hydroxyphenyl)-1-ethanone -Drug Synthesis Database

【结构式】

【分子编号】23810

【品名】1-(4-fluoro-2-hydroxyphenyl)-1-ethanone

【CA登记号】1481-27-2

【分子式】C₈H₇FO₂

【分子量】154.1407832

【元素组成】C 62.34% H 4.58% F 12.33% O 20.76%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Friedel-Crafts acylation of 3-fluorophenol (I) with acetic anhydride in the presence of AlCl3 at 120 C provided 4-fluoro-2-hydroxy-acetophenone (II). Subsequent treatment of (II) with phthaloyl chloride (III) in pyridine afforded diester (IV). Heating of (IV) with K2CO3 in pyridine, followed by acidic work-up yielded the title flavone.

参考文献中间体

合成目标

【1】 Belluti, F.; Carrara, M.; Rampa, A.; Gobbi, S.; Da Re, P.; Valenti, P.; Cima, L.; Bisi, A.; Synthesis of flavone-2'-carboxylic acid analogues. Anti-Cancer Drug Des 1998, 13, 8, 881.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23809	3-fluorophenol	372-20-3	C₆H₅FO	详情	详情
(II)	23810	1-(4-fluoro-2-hydroxyphenyl)-1-ethanone	1481-27-2	C₈H₇FO₂	详情	详情
(III)	23811	phthaloyl dichloride;1,2-Benzenedicarbonyl dichloride;o-Phthaloyl chloride	88-95-9	C₈H₄Cl₂O₂	详情	详情
(IV)	23812	bis(2-acetyl-5-fluorophenyl) phthalate		C₂₄H₁₆F₂O₆	详情	详情

Extended Information