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【结 构 式】 
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【药物名称】 【化学名称】2-(7-Fluoro-4-oxo-4H-1-benzopyran-2-yl)benzoic acid 【CA登记号】 【 分 子 式 】C16H9FO4 【 分 子 量 】284.24613 |
【开发单位】Università degli Studi di Bologna (Originator), Università degli Studi di Milano (Originator), Università degli Studi di Padova (Originator) 【药理作用】ONCOLYTIC DRUGS |
合成路线1
Friedel-Crafts acylation of 3-fluorophenol (I) with acetic anhydride in the presence of AlCl3 at 120 C provided 4-fluoro-2-hydroxy-acetophenone (II). Subsequent treatment of (II) with phthaloyl chloride (III) in pyridine afforded diester (IV). Heating of (IV) with K2CO3 in pyridine, followed by acidic work-up yielded the title flavone.
| 【1】 Belluti, F.; Carrara, M.; Rampa, A.; Gobbi, S.; Da Re, P.; Valenti, P.; Cima, L.; Bisi, A.; Synthesis of flavone-2'-carboxylic acid analogues. Anti-Cancer Drug Des 1998, 13, 8, 881. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23809 | 3-fluorophenol | 372-20-3 | C6H5FO | 详情 | 详情 |
| (II) | 23810 | 1-(4-fluoro-2-hydroxyphenyl)-1-ethanone | 1481-27-2 | C8H7FO2 | 详情 | 详情 |
| (III) | 23811 | phthaloyl dichloride;1,2-Benzenedicarbonyl dichloride;o-Phthaloyl chloride | 88-95-9 | C8H4Cl2O2 | 详情 | 详情 |
| (IV) | 23812 | bis(2-acetyl-5-fluorophenyl) phthalate | C24H16F2O6 | 详情 | 详情 |
Extended Information