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【结 构 式】 
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【分子编号】23766 【品名】3-aminophenol 【CA登记号】591-27-5 |
【 分 子 式 】C6H7NO 【 分 子 量 】109.12772 【元素组成】C 66.04% H 6.47% N 12.84% O 14.66% |
合成路线1
该中间体在本合成路线中的序号：(I)Alkylation of 3-aminophenol (I) with 2-(chloromethyl)quinoline (A) in a mixture of DMSO and THF employing sodium hydride as the base affords the intermediate amine (II). This amine is reacted with trifluoromethanesulfonic anhydride in toluene employing potassium carbonate as a base to afford ritolukast.
| 【1】 Musser, J.H.; Kubrak, D.M.; Kreft, A.F. (American Home Products Corp.); Quinoline compounds as antiallergy and antithrombotic agents. EP 0232954; GB 2185741; JP 1987190159; US 4675405 . |
| 【2】 Kreft, A.; Musser, J.; Daniel, W.C.; Hand, J.; RITOLUKAST < USAN >. Drugs Fut 1990, 15, 12, 1191. |
| 【3】 Musser, J.H.; Kreft, A.F.; Bender, R.H.W.; Kubrak, D.M.; Carlson, R.P.; Chang, J.; Hand, J.M.; N-[(Arylmethoxy)phenyl] and N-[(arylmethoxy)naphthyl]sulfonamides. Potent orally active leukotriene D4 antagonists of novel structure. J Med Chem 1989, 32, 6, 1176. |
合成路线2
该中间体在本合成路线中的序号：(I)The reaction of 3-aminophenol (I) with pivaloyl chloride and then with DHP and TsOH gives the protected pivalanilide (II), which is condensed with ethyl chloroformate by means of BuLi in THF yielding the benzoate ester (III). The condensation of benzoate (III) with acetophenone (IV) by means of NaH in refluxing dioxane affords the intermediate diketone (V), which, without purification, was treated with HCl in ethanol at room temperature to give the protected flavone (VI). Finally, thee removal of the two pivaloyl protecting groups was effected with HCl in refluxing ethanol.
| 【1】 Akama, T.; et al.; Novel 5-aminoflavone derivatives as specific antitumor agents in breast cancer. J Med Chem 1996, 39, 18, 3461. |
| 【2】 Shida, Y.; Sagaya, T.; Gomi, K.; Kasai, M.; Morimoto, M. (Kyowa Hakko Kogyo Co., Ltd.); 5-Aminoflavone derivs.. EP 0374789; JP 1990256673 . |
| 【3】 Sugaya, T.; et al.; Synthesis of a 6H-pyrazolo[4,5,1-de]acridin-6-one derivative: A useful intermediate of antitumor agents. Synthesis 1994, 73. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 13597 | 2,2-Dimethylpropanoyl chloride; Pivaloyl chloride | 3282-30-2 | C5H9ClO | 详情 | 详情 | |
| (I) | 23766 | 3-aminophenol | 591-27-5 | C6H7NO | 详情 | 详情 |
| (II) | 36663 | 2,2-dimethyl-N-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]propanamide | C16H23NO3 | 详情 | 详情 | |
| (III) | 36664 | ethyl 2-[(2,2-dimethylpropanoyl)(ethoxycarbonyl)amino]-6-(tetrahydro-2H-pyran-2-yloxy)benzoate | C22H31NO7 | 详情 | 详情 | |
| (IV) | 36665 | N-(4-acetylphenyl)-2,2-dimethylpropanamide | C13H17NO2 | 详情 | 详情 | |
| (V) | 36666 | N-[2-(3-[4-[(2,2-dimethylpropanoyl)amino]phenyl]-3-oxopropanoyl)-3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2,2-dimethylpropanamide | C30H38N2O6 | 详情 | 详情 | |
| (VI) | 36667 | N-(4-[5-[(2,2-dimethylpropanoyl)amino]-4-oxo-4H-chromen-2-yl]phenyl)-2,2-dimethylpropanamide | C25H28N2O4 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(IV)The cyclization of 4,5-dimethoxyanthranilic acid (I) with formamide by heating at 190 C gives 6,7-dimethoxyquinazoline (II), which is treated with refluxing SOCl2 to yield 4-chloro-6,7-dimethoxyquinazoline (III). Finally, this compound is condensed with 3-aminophenol (IV) in refluxing THF.
| 【1】 Barker, A.J. (AstraZeneca plc); Quinazoline derivs.. CA 2086968; EP 0566226; JP 1994073025; US 5616582 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23763 | 2-amino-4,5-dimethoxybenzoic acid | 5653-40-7 | C9H11NO4 | 详情 | 详情 |
| (II) | 23764 | 6,7-dimethoxyquinazoline; 6-methoxy-7-quinazolinyl methyl ether | C10H10N2O2 | 详情 | 详情 | |
| (III) | 23765 | 4-chloro-6,7-dimethoxyquinazoline; 4-chloro-6-methoxy-7-quinazolinyl methyl ether | C10H9ClN2O2 | 详情 | 详情 | |
| (IV) | 23766 | 3-aminophenol | 591-27-5 | C6H7NO | 详情 | 详情 |