• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】36665

【品名】N-(4-acetylphenyl)-2,2-dimethylpropanamide

【CA登记号】

【 分 子 式 】C13H17NO2

【 分 子 量 】219.28352

【元素组成】C 71.21% H 7.81% N 6.39% O 14.59%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The reaction of 3-aminophenol (I) with pivaloyl chloride and then with DHP and TsOH gives the protected pivalanilide (II), which is condensed with ethyl chloroformate by means of BuLi in THF yielding the benzoate ester (III). The condensation of benzoate (III) with acetophenone (IV) by means of NaH in refluxing dioxane affords the intermediate diketone (V), which, without purification, was treated with HCl in ethanol at room temperature to give the protected flavone (VI). Finally, thee removal of the two pivaloyl protecting groups was effected with HCl in refluxing ethanol.

1 Akama, T.; et al.; Novel 5-aminoflavone derivatives as specific antitumor agents in breast cancer. J Med Chem 1996, 39, 18, 3461.
2 Shida, Y.; Sagaya, T.; Gomi, K.; Kasai, M.; Morimoto, M. (Kyowa Hakko Kogyo Co., Ltd.); 5-Aminoflavone derivs.. EP 0374789; JP 1990256673 .
3 Sugaya, T.; et al.; Synthesis of a 6H-pyrazolo[4,5,1-de]acridin-6-one derivative: A useful intermediate of antitumor agents. Synthesis 1994, 73.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
13597 2,2-Dimethylpropanoyl chloride; Pivaloyl chloride 3282-30-2 C5H9ClO 详情 详情
(I) 23766 3-aminophenol 591-27-5 C6H7NO 详情 详情
(II) 36663 2,2-dimethyl-N-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]propanamide C16H23NO3 详情 详情
(III) 36664 ethyl 2-[(2,2-dimethylpropanoyl)(ethoxycarbonyl)amino]-6-(tetrahydro-2H-pyran-2-yloxy)benzoate C22H31NO7 详情 详情
(IV) 36665 N-(4-acetylphenyl)-2,2-dimethylpropanamide C13H17NO2 详情 详情
(V) 36666 N-[2-(3-[4-[(2,2-dimethylpropanoyl)amino]phenyl]-3-oxopropanoyl)-3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2,2-dimethylpropanamide C30H38N2O6 详情 详情
(VI) 36667 N-(4-[5-[(2,2-dimethylpropanoyl)amino]-4-oxo-4H-chromen-2-yl]phenyl)-2,2-dimethylpropanamide C25H28N2O4 详情 详情
Extended Information