|
【结 构 式】 
|
【分子编号】23764 【品名】6,7-dimethoxyquinazoline; 6-methoxy-7-quinazolinyl methyl ether 【CA登记号】 |
【 分 子 式 】C10H10N2O2 【 分 子 量 】190.20168 【元素组成】C 63.15% H 5.3% N 14.73% O 16.82% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The cyclization of 4,5-dimethoxyanthranilic acid (I) with formamide by heating at 190 C gives 6,7-dimethoxyquinazoline (II), which is treated with refluxing SOCl2 to yield 4-chloro-6,7-dimethoxyquinazoline (III). Finally, this compound is condensed with 3-aminophenol (IV) in refluxing THF.
| 【1】 Barker, A.J. (AstraZeneca plc); Quinazoline derivs.. CA 2086968; EP 0566226; JP 1994073025; US 5616582 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23763 | 2-amino-4,5-dimethoxybenzoic acid | 5653-40-7 | C9H11NO4 | 详情 | 详情 |
| (II) | 23764 | 6,7-dimethoxyquinazoline; 6-methoxy-7-quinazolinyl methyl ether | C10H10N2O2 | 详情 | 详情 | |
| (III) | 23765 | 4-chloro-6,7-dimethoxyquinazoline; 4-chloro-6-methoxy-7-quinazolinyl methyl ether | C10H9ClN2O2 | 详情 | 详情 | |
| (IV) | 23766 | 3-aminophenol | 591-27-5 | C6H7NO | 详情 | 详情 |
Extended Information