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【结 构 式】 
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【分子编号】22830 【品名】ethyl 4-fluorobenzoate 【CA登记号】451-46-7 |
【 分 子 式 】C9H9FO2 【 分 子 量 】168.1676632 【元素组成】C 64.28% H 5.39% F 11.3% O 19.03% |
合成路线1
该中间体在本合成路线中的序号：(II)The lithium derivative of 4-picoline (I) was acylated with ethyl 4-fluorobenzoate (II) to afford ketone (III). Condensation of (III) with dimethylformamide dimethylacetal provided enaminone (IV) which was subsequently cyclized with hydroxylamine to give the diaryl isoxazole (V). Isoxazole ring opening in (V) under basic conditions led to keto nitrile (VI). Chlorination of (VI) by means of POCl3, followed by reaction with hydrazine, furnished the amino pyrazole (VII). The diazonium salt (VIII) prepared from amino pyrazole (VII) was then added to the phosphorane aldehyde (IX) to generate the pyrazolotriazine (X). Hydrogenation of the triazine ring of (X) employing NaBH3CN produced the tetrahydro pyrazolotriazine (XI). This was finally acylated by phenylglyoxylic acid (XII) to yield the target alpha-oxo amide.
| 【1】 Kawai, Y.; Yamazaki, H.; Tanaka, H.; Oku, T. (Fujisawa Pharmaceutical Co., Ltd.); Pyrazolitriazines with interleukin-1 and tumour necrosis factor inhibitory activity. EP 0686156; JP 1996507056; WO 9419350 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 31150 | 4-methylpyridine | 108-89-4 | C6H7N | 详情 | 详情 |
| (II) | 22830 | ethyl 4-fluorobenzoate | 451-46-7 | C9H9FO2 | 详情 | 详情 |
| (III) | 45005 | 1-(4-fluorophenyl)-2-(4-pyridinyl)-1-ethanone | C13H10FNO | 详情 | 详情 | |
| (IV) | 55996 | (Z)-3-(dimethylamino)-1-(4-fluorophenyl)-2-(4-pyridinyl)-2-propen-1-one | C16H15FN2O | 详情 | 详情 | |
| (V) | 55997 | 4-[5-(4-fluorophenyl)-4-isoxazolyl]pyridine | C14H9FN2O | 详情 | 详情 | |
| (VI) | 55998 | 3-(4-fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile | C14H9FN2O | 详情 | 详情 | |
| (VII) | 55999 | 5-(4-fluorophenyl)-4-(4-pyridinyl)-1H-pyrazol-3-ylamine; 5-(4-fluorophenyl)-4-(4-pyridinyl)-1H-pyrazol-3-amine | C14H11FN4 | 详情 | 详情 | |
| (VIII) | 56000 | 5-(4-fluorophenyl)-4-(4-pyridinyl)-1H-pyrazole-3-diazonium | C14H9FN5 | 详情 | 详情 | |
| (IX) | 55468 | 2-(triphenylphosphoranylidene)acetaldehyde | C20H17OP | 详情 | 详情 | |
| (X) | 56001 | 7-(4-fluorophenyl)-8-(4-pyridinyl)pyrazolo[5,1-c][1,2,4]triazine | C16H10FN5 | 详情 | 详情 | |
| (XI) | 56002 | 7-(4-fluorophenyl)-8-(4-pyridinyl)-1,2,3,4-tetrahydropyrazolo[5,1-c][1,2,4]triazine | C16H14FN5 | 详情 | 详情 | |
| (XII) | 55589 | Benzoylformic acid; Phenylglyoxylic acid | 611-73-4 | C8H6O3 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(II)Condensation of 4-(tert-butyldimethylsilyloxymethyl)pyridine (I) with ethyl 4-fluorobenzoate (II) using NaHMDS gave the silyloxyketone (III). Then, cyclization of (III) with 2,6-diamino-4-methoxypyridine (IV) in the presence of H2SO4 in refluxing dimethoxyethane provided the target pyrrolopyridine.
| 【1】 Henry, J.R.; Rupert, K.C.; Dodd, J.H.; Turchi, I.J.; Wadsworth, S.A.; Cavender, D.E.; Fahmy, B.; Olini, G.C.; Davis, J.E.; Pellegrino-Gensey, J.L.; Schafer, P.H.; Siekierka, J.J.; 6-Amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl). J Med Chem 1998, 41, 22, 4196. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22829 | 4-([[tert-butyl(dimethyl)silyl]oxy]methyl)pyridine; tert-butyl(dimethyl)silyl 4-pyridinylmethyl ether | C12H21NOSi | 详情 | 详情 | |
| (II) | 22830 | ethyl 4-fluorobenzoate | 451-46-7 | C9H9FO2 | 详情 | 详情 |
| (III) | 22831 | 2-[[tert-butyl(dimethyl)silyl]oxy]-1-(4-fluorophenyl)-2-(4-pyridinyl)-1-ethanone | C19H24FNO2Si | 详情 | 详情 | |
| (IV) | 22832 | 4-methoxy-2,6-pyridinediamine; 6-amino-4-methoxy-2-pyridinylamine | C6H9N3O | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(II)Sylilated hydroxymethylpyridine (I) was condensed with ethyl 4-fluorobenzoate (II) in the presence of sodium hemamethyldisilazide to produce the silyloxy ketone (III). Subsequent reaction of (III) with diaminopyrimidine (IV) in the presence of H2SO4 in refluxing dimethoxyethane yielded the title pyrrolopyridine.
| 【1】 Henry, J.R.; Rupert, K.C.; Dodd, J.H.; Turchi, I.J.; Wadsworth, S.A.; Cavender, D.E.; Schafer, P.H.; Siekierka, J.J.; Potent inhibitors of the MAP kinase p38. Bioorg Med Chem Lett 1998, 8, 23, 3335. |
| 【2】 Dodd, J.H.; Henry, J.R.; Rupert, K. (Ortho-McNeil Pharmaceutical, Inc.); Substd. pyrrolopyridines useful in the treatment of inflammatory diseases. WO 9847899 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22829 | 4-([[tert-butyl(dimethyl)silyl]oxy]methyl)pyridine; tert-butyl(dimethyl)silyl 4-pyridinylmethyl ether | C12H21NOSi | 详情 | 详情 | |
| (II) | 22830 | ethyl 4-fluorobenzoate | 451-46-7 | C9H9FO2 | 详情 | 详情 |
| (III) | 22831 | 2-[[tert-butyl(dimethyl)silyl]oxy]-1-(4-fluorophenyl)-2-(4-pyridinyl)-1-ethanone | C19H24FNO2Si | 详情 | 详情 | |
| (IV) | 26862 | 4-(benzyloxy)-2,6-pyridinediamine | C12H13N3O | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(III)4-Methyl-2-(methylsulfanyl)pyrimidine (II) was prepared by methylation of mercaptopyrimidine (I) with dimethylformamide dimethylacetal (1). Condensation of the lithium anion of (II) with ethyl 4-fluorobenzoate (III) produced the diaryl ethanone (IV), which was further oxidized to diketone (V) by using HBr in DMSO. The target imidazole intermediate (VII) was then obtained by condensation of diketone (V) with glyoxal dimethylacetal (VI) in the presence of ammonium acetate.
| 【1】 Collis, A.J.; Wilsher, N.E.; Foster, M.L.; Redford, E.J.; McLay, I.M.; Page, K.M.; Maslen, C.; Halley, F.; Souness, J.E.; RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency. Bioorg Med Chem Lett 2001, 11, 5, 693. |
| 【2】 Halley, F.; Porter, B.; Bamborough, P.L.; Lewis, R.A.; Ratcliffe, A.J.; Wallace, P.A.; McLay, I.M.; McKenna, J.M.; Lythgoe, D.J.; Collis, A.J. (Rhone-Poulenc Rorer Ltd.); Imidazolyl-cyclic acetals. EP 0988301; WO 9856788 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 49196 | 4-methyl-2-pyrimidinylhydrosulfide; 4-methyl-2-pyrimidinethiol | C5H6N2S | 详情 | 详情 | |
| (II) | 49197 | 4-methyl-2-(methylsulfanyl)pyrimidine; methyl 4-methyl-2-pyrimidinyl sulfide | C6H8N2S | 详情 | 详情 | |
| (III) | 22830 | ethyl 4-fluorobenzoate | 451-46-7 | C9H9FO2 | 详情 | 详情 |
| (IV) | 49198 | 1-(4-fluorophenyl)-2-[2-(methylsulfanyl)-4-pyrimidinyl]-1-ethanone | C13H11FN2OS | 详情 | 详情 | |
| (V) | 49199 | 1-(4-fluorophenyl)-2-[2-(methylsulfanyl)-4-pyrimidinyl]-1,2-ethanedione | C13H9FN2O2S | 详情 | 详情 | |
| (VI) | 49200 | 2,2-dimethoxyacetaldehyde | C4H8O3 | 详情 | 详情 | |
| (VII) | 49201 | 4-(4-fluorophenyl)-5-[2-(methylsulfanyl)-4-pyrimidinyl]-1H-imidazole-2-carbaldehyde | C15H11FN4OS | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(I)Condensation of ethyl 4-fluorobenzoate (I) with 4-piperidone ethylene ketal (II) afforded the N-arylpiperidine (III). Saponification of the ethyl ester group of (III), followed by acidic hydrolysis of the ethylene ketal function, yielded the benzoic acid derivative (V). Coupling of acid (V) with leucine ethyl ester (VI) using EDC gave amide (VII). Then, reductive amination of piperidone (VII) with the known arylethanolamine (VIII) using NaBH(OAc)3 furnished the aminopiperidine (IX). The ethyl ester group of (IX) was finally hydrolyzed with NaOH to provide the corresponding carboxylic acid.
| 【1】 Hu, B.; et al.; (4-Piperidin-1-yl)phenyl amides: Potent and selective human beta3 agonists. J Med Chem 2001, 44, 9, 1456. |
| 【2】 Taylor, E.C.; Skotnicki, J.S.; A convenient synthesis of 1-aryl-4-piperidones. Synthesis 1981, 606. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22830 | ethyl 4-fluorobenzoate | 451-46-7 | C9H9FO2 | 详情 | 详情 |
| (II) | 11338 | 1,4-Dioxa-8-azaspiro[4.5]decane; 4-Piperidone ethylene ketal | 177-11-7 | C7H13NO2 | 详情 | 详情 |
| (III) | 50886 | ethyl 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)benzoate | C16H21NO4 | 详情 | 详情 | |
| (IV) | 50887 | 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)benzoic acid | C14H17NO4 | 详情 | 详情 | |
| (V) | 50888 | 4-(4-oxo-1-piperidinyl)benzoic acid | C12H13NO3 | 详情 | 详情 | |
| (VI) | 50889 | ethyl (2S)-2-amino-4-methylpentanoate | C8H17NO2 | 详情 | 详情 | |
| (VII) | 50890 | ethyl (2S)-4-methyl-2-[[4-(4-oxo-1-piperidinyl)benzoyl]amino]pentanoate | C20H28N2O4 | 详情 | 详情 | |
| (VIII) | 49404 | N-[5-[(1R)-2-amino-1-hydroxyethyl]-2-hydroxyphenyl]methanesulfonamide | C9H14N2O4S | 详情 | 详情 | |
| (IX) | 50891 | ethyl (2S)-2-[(4-[4-[((2R)-2-hydroxy-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethyl)amino]-1-piperidinyl]benzoyl)amino]-4-methylpentanoate | C29H42N4O7S | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(II)Condensation of 2-fluoro-4-methylpyridine (I) with ethyl 4-fluorobenzoate (II) by means of sodium bis(trimethylsilyl)amide provides the diaryl ethanone (III). Subsequent nitrosation of ketone (III) with tert-butyl nitrite under acidic conditions furnishes oxime (IV). Cyclization of keto oxime (IV) with trimethylacetaldehyde (V) in the presence of ammonium acetate in boiling AcOH proceeds with concomitant hydrolysis of the fluoro group to produce the N-hydroxy imidazole (VI). Reduction of (VI) employing TiCl3 gives imidazole (VII). Finally, the photochemical cyclization of diarylimidazole (VII) leads to the target tetracyclic compound (1, 2).
| 【1】 Thompson, J.E.; Cubbon, R.M.; Cummings, R.T.; Wicker, L.S.; Franksun, R.; Cunningham, B.R.; Cameron, P.M.; Meinke, P.T.; Liverton, N.; Weng, Y.; DeMartino, J.A.; Photochemical preparation of a pyridone containing tetracycle: A jak protein kinase inhibitor. Bioorg Med Chem Lett 2002, 12, 8, 1219. |
| 【2】 Sinclair, P.J.; Goulet, J.L.; Hong, X.; Thompson, J.E.; Cubbon, R.M.; Cummings, R.T. (Merck & Co., Inc.); Benzimidazo[4,5-f]isoquinolinone derivs.. WO 0311285 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18296 | 2-Fluoro-4-methylpyridine | 461-87-0 | C6H6FN | 详情 | 详情 |
| (II) | 22830 | ethyl 4-fluorobenzoate | 451-46-7 | C9H9FO2 | 详情 | 详情 |
| (III) | 63664 | 1-(4-fluorophenyl)-2-(2-fluoro-4-pyridinyl)-1-ethanone | C13H9F2NO | 详情 | 详情 | |
| (IV) | 63665 | 1-(4-fluorophenyl)-2-(2-fluoro-4-pyridinyl)-1,2-ethanedione 2-oxime | C13H8F2N2O2 | 详情 | 详情 | |
| (V) | 19797 | Trimethylacetaldehyde; pivalaldehyde; 2,2-Dimethylpropionaldehyde; 2,2-Dimethylpropanal | 630-19-3 | C5H10O | 详情 | 详情 |
| (VI) | 63666 | 4-[2-(tert-butyl)-4-(4-fluorophenyl)-1-hydroxy-1H-imidazol-5-yl]-2(1H)-pyridinone | C18H18FN3O2 | 详情 | 详情 | |
| (VII) | 63667 | 4-[2-(tert-butyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2(1H)-pyridinone | C18H18FN3O | 详情 | 详情 |