4-methoxy-2,6-pyridinediamine; 6-amino-4-methoxy-2-pyridinylamine -Drug Synthesis Database

【结构式】

【分子编号】22832

【品名】4-methoxy-2,6-pyridinediamine; 6-amino-4-methoxy-2-pyridinylamine

【CA登记号】

【分子式】C₆H₉N₃O

【分子量】139.15708

【元素组成】C 51.79% H 6.52% N 30.2% O 11.5%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Condensation of 4-(tert-butyldimethylsilyloxymethyl)pyridine (I) with ethyl 4-fluorobenzoate (II) using NaHMDS gave the silyloxyketone (III). Then, cyclization of (III) with 2,6-diamino-4-methoxypyridine (IV) in the presence of H2SO4 in refluxing dimethoxyethane provided the target pyrrolopyridine.

参考文献中间体

合成目标

【1】 Henry, J.R.; Rupert, K.C.; Dodd, J.H.; Turchi, I.J.; Wadsworth, S.A.; Cavender, D.E.; Fahmy, B.; Olini, G.C.; Davis, J.E.; Pellegrino-Gensey, J.L.; Schafer, P.H.; Siekierka, J.J.; 6-Amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl). J Med Chem 1998, 41, 22, 4196.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	22829	4-([[tert-butyl(dimethyl)silyl]oxy]methyl)pyridine; tert-butyl(dimethyl)silyl 4-pyridinylmethyl ether		C₁₂H₂₁NOSi	详情	详情
(II)	22830	ethyl 4-fluorobenzoate	451-46-7	C₉H₉FO₂	详情	详情
(III)	22831	2-[[tert-butyl(dimethyl)silyl]oxy]-1-(4-fluorophenyl)-2-(4-pyridinyl)-1-ethanone		C₁₉H₂₄FNO₂Si	详情	详情
(IV)	22832	4-methoxy-2,6-pyridinediamine; 6-amino-4-methoxy-2-pyridinylamine		C₆H₉N₃O	详情	详情

Extended Information