4-(benzyloxy)-2,6-pyridinediamine -Drug Synthesis Database

【结构式】

【分子编号】26862

【品名】4-(benzyloxy)-2,6-pyridinediamine

【CA登记号】

【分子式】C₁₂H₁₃N₃O

【分子量】215.25484

【元素组成】C 66.96% H 6.09% N 19.52% O 7.43%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Sylilated hydroxymethylpyridine (I) was condensed with ethyl 4-fluorobenzoate (II) in the presence of sodium hemamethyldisilazide to produce the silyloxy ketone (III). Subsequent reaction of (III) with diaminopyrimidine (IV) in the presence of H2SO4 in refluxing dimethoxyethane yielded the title pyrrolopyridine.

参考文献中间体

合成目标

【1】 Henry, J.R.; Rupert, K.C.; Dodd, J.H.; Turchi, I.J.; Wadsworth, S.A.; Cavender, D.E.; Schafer, P.H.; Siekierka, J.J.; Potent inhibitors of the MAP kinase p38. Bioorg Med Chem Lett 1998, 8, 23, 3335.
【2】 Dodd, J.H.; Henry, J.R.; Rupert, K. (Ortho-McNeil Pharmaceutical, Inc.); Substd. pyrrolopyridines useful in the treatment of inflammatory diseases. WO 9847899 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	22829	4-([[tert-butyl(dimethyl)silyl]oxy]methyl)pyridine; tert-butyl(dimethyl)silyl 4-pyridinylmethyl ether		C₁₂H₂₁NOSi	详情	详情
(II)	22830	ethyl 4-fluorobenzoate	451-46-7	C₉H₉FO₂	详情	详情
(III)	22831	2-[[tert-butyl(dimethyl)silyl]oxy]-1-(4-fluorophenyl)-2-(4-pyridinyl)-1-ethanone		C₁₉H₂₄FNO₂Si	详情	详情
(IV)	26862	4-(benzyloxy)-2,6-pyridinediamine		C₁₂H₁₃N₃O	详情	详情

Extended Information