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【结 构 式】

【分子编号】22797

【品名】(1R,2R)-2-amino-1-phenyl-3-(1-pyrrolidinyl)-1-propanol

【CA登记号】

【 分 子 式 】C13H20N2O

【 分 子 量 】220.31468

【元素组成】C 70.87% H 9.15% N 12.72% O 7.26%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

(1R,2R)-2-Benzyloxycarbonylamino-1-phenyl-1,3-propanediol (I) was converted to mesylate (II) upon treatment with methanesulfonyl chloride in pyridine. Reaction of this mesylate with pyrrolidine (III) provided pyrrolidino compound (IV). The N-benzyloxycarbonyl group of (IV) was then eliminated by hydrogenolysis over Pd/C to yield the vicinal hydroxyamine (V), which was finally condensed with decanoyl chloride (VI) to furnish the target decanoyl amide.

1 Oyamada, H.; Inokuchi, J.; Jinbo, M. (Seikagaku Corp.); Amino alcohol deriv. and method for preparing the . EP 0782992 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 22793 phenyl (1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-phenylethylcarbamate C16H17NO4 详情 详情
(II) 22794 (2R,3R)-3-hydroxy-2-[(phenoxycarbonyl)amino]-3-phenylpropyl methanesulfonate C17H19NO6S 详情 详情
(III) 11376 Pyrrolidine 123-75-1 C4H9N 详情 详情
(IV) 22796 phenyl (1R,2R)-2-hydroxy-2-phenyl-1-(1-pyrrolidinylmethyl)ethylcarbamate C20H24N2O3 详情 详情
(V) 22797 (1R,2R)-2-amino-1-phenyl-3-(1-pyrrolidinyl)-1-propanol C13H20N2O 详情 详情
(VI) 22798 1-chloro-2-undecanone C11H21ClO 详情 详情
Extended Information