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【结 构 式】 
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【分子编号】22794 【品名】(2R,3R)-3-hydroxy-2-[(phenoxycarbonyl)amino]-3-phenylpropyl methanesulfonate 【CA登记号】 |
【 分 子 式 】C17H19NO6S 【 分 子 量 】365.407 【元素组成】C 55.88% H 5.24% N 3.83% O 26.27% S 8.78% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)(1R,2R)-2-Benzyloxycarbonylamino-1-phenyl-1,3-propanediol (I) was converted to mesylate (II) upon treatment with methanesulfonyl chloride in pyridine. Reaction of this mesylate with pyrrolidine (III) provided pyrrolidino compound (IV). The N-benzyloxycarbonyl group of (IV) was then eliminated by hydrogenolysis over Pd/C to yield the vicinal hydroxyamine (V), which was finally condensed with decanoyl chloride (VI) to furnish the target decanoyl amide.
| 【1】 Oyamada, H.; Inokuchi, J.; Jinbo, M. (Seikagaku Corp.); Amino alcohol deriv. and method for preparing the . EP 0782992 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22793 | phenyl (1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-phenylethylcarbamate | C16H17NO4 | 详情 | 详情 | |
| (II) | 22794 | (2R,3R)-3-hydroxy-2-[(phenoxycarbonyl)amino]-3-phenylpropyl methanesulfonate | C17H19NO6S | 详情 | 详情 | |
| (III) | 11376 | Pyrrolidine | 123-75-1 | C4H9N | 详情 | 详情 |
| (IV) | 22796 | phenyl (1R,2R)-2-hydroxy-2-phenyl-1-(1-pyrrolidinylmethyl)ethylcarbamate | C20H24N2O3 | 详情 | 详情 | |
| (V) | 22797 | (1R,2R)-2-amino-1-phenyl-3-(1-pyrrolidinyl)-1-propanol | C13H20N2O | 详情 | 详情 | |
| (VI) | 22798 | 1-chloro-2-undecanone | C11H21ClO | 详情 | 详情 |
Extended Information