phenyl (1R,2R)-2-hydroxy-2-phenyl-1-(1-pyrrolidinylmethyl)ethylcarbamate -Drug Synthesis Database

【结构式】

【分子编号】22796

【品名】phenyl (1R,2R)-2-hydroxy-2-phenyl-1-(1-pyrrolidinylmethyl)ethylcarbamate

【CA登记号】

【分子式】C₂₀H₂₄N₂O₃

【分子量】340.42224

【元素组成】C 70.57% H 7.11% N 8.23% O 14.1%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

(1R,2R)-2-Benzyloxycarbonylamino-1-phenyl-1,3-propanediol (I) was converted to mesylate (II) upon treatment with methanesulfonyl chloride in pyridine. Reaction of this mesylate with pyrrolidine (III) provided pyrrolidino compound (IV). The N-benzyloxycarbonyl group of (IV) was then eliminated by hydrogenolysis over Pd/C to yield the vicinal hydroxyamine (V), which was finally condensed with decanoyl chloride (VI) to furnish the target decanoyl amide.

参考文献中间体

合成目标

【1】 Oyamada, H.; Inokuchi, J.; Jinbo, M. (Seikagaku Corp.); Amino alcohol deriv. and method for preparing the . EP 0782992 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	22793	phenyl (1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-phenylethylcarbamate		C₁₆H₁₇NO₄	详情	详情
(II)	22794	(2R,3R)-3-hydroxy-2-[(phenoxycarbonyl)amino]-3-phenylpropyl methanesulfonate		C₁₇H₁₉NO₆S	详情	详情
(III)	11376	Pyrrolidine	123-75-1	C₄H₉N	详情	详情
(IV)	22796	phenyl (1R,2R)-2-hydroxy-2-phenyl-1-(1-pyrrolidinylmethyl)ethylcarbamate		C₂₀H₂₄N₂O₃	详情	详情
(V)	22797	(1R,2R)-2-amino-1-phenyl-3-(1-pyrrolidinyl)-1-propanol		C₁₃H₂₀N₂O	详情	详情
(VI)	22798	1-chloro-2-undecanone		C₁₁H₂₁ClO	详情	详情

Extended Information