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【结 构 式】

【分子编号】19492

【品名】(E)-4-octenedioyl dichloride

【CA登记号】

【 分 子 式 】C8H10Cl2O2

【 分 子 量 】209.0716

【元素组成】C 45.96% H 4.82% Cl 33.91% O 15.31%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The optical resolution of (±)-5'-methoxylaudanosine with (-)-dibenzoyltartaric acid in methanol gives (R)-(-)-5'-methoxylaudanosine (I), which is condensed with 3-chloropropanol (II) by means of NaI and Na2CO3 in refluxing butanone yielding the quinolinium chloride derivative (III). Finally, this compound is esterified with 4(E)-octenedioyl chloride (IV) in hot 1,2-dichloroethane.

1 Swaringen, R.A. Jr.; El-Sayad, H.A.; Yeowell, D.A.; Savarese, J.J. (General Hospital Corporation; GlaxoSmithKline plc); Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts, their preparation and pharmaceutical compsns. containing them. EP 0181055; ES 8609260; JP 1986087666; JP 1986087666; US 4761419 .
2 Prous, J.; Castaner, J.; MIVACURIUM CHLORIDE < Rec INN; BAN >. Drugs Fut 1989, 14, 7, 632.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 19489 (1R)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline; 4-[[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl]-2,6-dimethoxyphenyl methyl ether C22H29NO5 详情 详情
(II) 19490 3-chloro-1-propanol 627-30-5 C3H7ClO 详情 详情
(III) 19491 (1R)-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium chloride C25H36ClNO6 详情 详情
(IV) 19492 (E)-4-octenedioyl dichloride C8H10Cl2O2 详情 详情
Extended Information