|
【结 构 式】 
|
【分子编号】19491 【品名】(1R)-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium chloride 【CA登记号】 |
【 分 子 式 】C25H36ClNO6 【 分 子 量 】482.01668 【元素组成】C 62.3% H 7.53% Cl 7.36% N 2.91% O 19.92% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The optical resolution of (±)-5'-methoxylaudanosine with (-)-dibenzoyltartaric acid in methanol gives (R)-(-)-5'-methoxylaudanosine (I), which is condensed with 3-chloropropanol (II) by means of NaI and Na2CO3 in refluxing butanone yielding the quinolinium chloride derivative (III). Finally, this compound is esterified with 4(E)-octenedioyl chloride (IV) in hot 1,2-dichloroethane.
| 【1】 Swaringen, R.A. Jr.; El-Sayad, H.A.; Yeowell, D.A.; Savarese, J.J. (General Hospital Corporation; GlaxoSmithKline plc); Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts, their preparation and pharmaceutical compsns. containing them. EP 0181055; ES 8609260; JP 1986087666; JP 1986087666; US 4761419 . |
| 【2】 Prous, J.; Castaner, J.; MIVACURIUM CHLORIDE < Rec INN; BAN >. Drugs Fut 1989, 14, 7, 632. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 19489 | (1R)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline; 4-[[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl]-2,6-dimethoxyphenyl methyl ether | C22H29NO5 | 详情 | 详情 | |
| (II) | 19490 | 3-chloro-1-propanol | 627-30-5 | C3H7ClO | 详情 | 详情 |
| (III) | 19491 | (1R)-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium chloride | C25H36ClNO6 | 详情 | 详情 | |
| (IV) | 19492 | (E)-4-octenedioyl dichloride | C8H10Cl2O2 | 详情 | 详情 |
Extended Information