5-(1-methylethylidene)-2-propyl-3-[[2'-(1-trityl-1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-3,5-dihydro-4H-imidazol-4-one -Drug Synthesis Database

【结构式】

【分子编号】18741

【品名】5-(1-methylethylidene)-2-propyl-3-[[2'-(1-trityl-1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-3,5-dihydro-4H-imidazol-4-one

【CA登记号】

【分子式】C₄₂H₃₈N₆O

【分子量】642.80356

【元素组成】C 78.48% H 5.96% N 13.07% O 2.49%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

Condensation of imidate (I) with glycine ethyl ester (II) in refluxing acetone yielded imidazolone (III). Subsequent alkylation with N-triphenylmethyl-5-[4'-bromomethyl)biphenyl-2-yl]tetrazole (IV) in the presence of potassium tert-butoxide in cold DMF provided (V), which was finally deprotected by refluxing in a methanolic solution of AcOH to afford the title compound.

参考文献中间体

合成目标

【1】 Okazaki, T.; et al.; Studies of nonpeptide angiotensin II receptor antagonists. III. Synthesis and biological evaluation of 5-alkylidine-3,5-dihydro-4H-imidazol-4-one derivatives. Chem Pharm Bull 1998, 46, 5, 777.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	23199	2-Propanone; Acetone; beta-ketopropane; chevron acetone;propan-2-one； Dimethyl formaldehyde; Dimethyl ketone; dimethylketal; Ketone propane; Methyl ketone; Propanone; Pyroacetic acid; Pyroacetic ether	67-64-1	C₃H₆O	详情	详情
(I)	18737	ethyl butanimidoate		C₆H₁₃NO	详情	详情
(II)	10309	ethyl 2-aminoacetate; Glycine ethyl ester	459-73-4	C₄H₉NO₂	详情	详情
(III)	18739	5-(1-methylethylidene)-2-propyl-3,5-dihydro-4H-imidazol-4-one		C₉H₁₄N₂O	详情	详情
(IV)	15538	5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-trityl-2H-1,2,3,4-tetraazole	124750-51-2	C₃₃H₂₅BrN₄	详情	详情
(V)	18741	5-(1-methylethylidene)-2-propyl-3-[[2'-(1-trityl-1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-3,5-dihydro-4H-imidazol-4-one		C₄₂H₃₈N₆O	详情	详情

Extended Information