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【结 构 式】

【分子编号】18739

【品名】5-(1-methylethylidene)-2-propyl-3,5-dihydro-4H-imidazol-4-one

【CA登记号】

【 分 子 式 】C9H14N2O

【 分 子 量 】166.22304

【元素组成】C 65.03% H 8.49% N 16.85% O 9.63%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Condensation of imidate (I) with glycine ethyl ester (II) in refluxing acetone yielded imidazolone (III). Subsequent alkylation with N-triphenylmethyl-5-[4'-bromomethyl)biphenyl-2-yl]tetrazole (IV) in the presence of potassium tert-butoxide in cold DMF provided (V), which was finally deprotected by refluxing in a methanolic solution of AcOH to afford the title compound.

1 Okazaki, T.; et al.; Studies of nonpeptide angiotensin II receptor antagonists. III. Synthesis and biological evaluation of 5-alkylidine-3,5-dihydro-4H-imidazol-4-one derivatives. Chem Pharm Bull 1998, 46, 5, 777.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
23199 2-Propanone; Acetone; beta-ketopropane; chevron acetone;propan-2-one; Dimethyl formaldehyde; Dimethyl ketone; dimethylketal; Ketone propane; Methyl ketone; Propanone; Pyroacetic acid; Pyroacetic ether 67-64-1 C3H6O 详情 详情
(I) 18737 ethyl butanimidoate C6H13NO 详情 详情
(II) 10309 ethyl 2-aminoacetate; Glycine ethyl ester 459-73-4 C4H9NO2 详情 详情
(III) 18739 5-(1-methylethylidene)-2-propyl-3,5-dihydro-4H-imidazol-4-one C9H14N2O 详情 详情
(IV) 15538 5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-trityl-2H-1,2,3,4-tetraazole 124750-51-2 C33H25BrN4 详情 详情
(V) 18741 5-(1-methylethylidene)-2-propyl-3-[[2'-(1-trityl-1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-3,5-dihydro-4H-imidazol-4-one C42H38N6O 详情 详情
Extended Information