【结 构 式】 |
【分子编号】18739 【品名】5-(1-methylethylidene)-2-propyl-3,5-dihydro-4H-imidazol-4-one 【CA登记号】 |
【 分 子 式 】C9H14N2O 【 分 子 量 】166.22304 【元素组成】C 65.03% H 8.49% N 16.85% O 9.63% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)Condensation of imidate (I) with glycine ethyl ester (II) in refluxing acetone yielded imidazolone (III). Subsequent alkylation with N-triphenylmethyl-5-[4'-bromomethyl)biphenyl-2-yl]tetrazole (IV) in the presence of potassium tert-butoxide in cold DMF provided (V), which was finally deprotected by refluxing in a methanolic solution of AcOH to afford the title compound.
【1】 Okazaki, T.; et al.; Studies of nonpeptide angiotensin II receptor antagonists. III. Synthesis and biological evaluation of 5-alkylidine-3,5-dihydro-4H-imidazol-4-one derivatives. Chem Pharm Bull 1998, 46, 5, 777. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
23199 | 2-Propanone; Acetone; beta-ketopropane; chevron acetone;propan-2-one; Dimethyl formaldehyde; Dimethyl ketone; dimethylketal; Ketone propane; Methyl ketone; Propanone; Pyroacetic acid; Pyroacetic ether | 67-64-1 | C3H6O | 详情 | 详情 | |
(I) | 18737 | ethyl butanimidoate | C6H13NO | 详情 | 详情 | |
(II) | 10309 | ethyl 2-aminoacetate; Glycine ethyl ester | 459-73-4 | C4H9NO2 | 详情 | 详情 |
(III) | 18739 | 5-(1-methylethylidene)-2-propyl-3,5-dihydro-4H-imidazol-4-one | C9H14N2O | 详情 | 详情 | |
(IV) | 15538 | 5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-trityl-2H-1,2,3,4-tetraazole | 124750-51-2 | C33H25BrN4 | 详情 | 详情 |
(V) | 18741 | 5-(1-methylethylidene)-2-propyl-3-[[2'-(1-trityl-1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-3,5-dihydro-4H-imidazol-4-one | C42H38N6O | 详情 | 详情 |
Extended Information