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【结 构 式】 
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【分子编号】18737 【品名】ethyl butanimidoate 【CA登记号】 |
【 分 子 式 】C6H13NO 【 分 子 量 】115.17536 【元素组成】C 62.57% H 11.38% N 12.16% O 13.89% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Condensation of imidate (I) with glycine ethyl ester (II) in refluxing acetone yielded imidazolone (III). Subsequent alkylation with N-triphenylmethyl-5-[4'-bromomethyl)biphenyl-2-yl]tetrazole (IV) in the presence of potassium tert-butoxide in cold DMF provided (V), which was finally deprotected by refluxing in a methanolic solution of AcOH to afford the title compound.
| 【1】 Okazaki, T.; et al.; Studies of nonpeptide angiotensin II receptor antagonists. III. Synthesis and biological evaluation of 5-alkylidine-3,5-dihydro-4H-imidazol-4-one derivatives. Chem Pharm Bull 1998, 46, 5, 777. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 23199 | 2-Propanone; Acetone; beta-ketopropane; chevron acetone;propan-2-one； Dimethyl formaldehyde; Dimethyl ketone; dimethylketal; Ketone propane; Methyl ketone; Propanone; Pyroacetic acid; Pyroacetic ether | 67-64-1 | C3H6O | 详情 | 详情 | |
| (I) | 18737 | ethyl butanimidoate | C6H13NO | 详情 | 详情 | |
| (II) | 10309 | ethyl 2-aminoacetate; Glycine ethyl ester | 459-73-4 | C4H9NO2 | 详情 | 详情 |
| (III) | 18739 | 5-(1-methylethylidene)-2-propyl-3,5-dihydro-4H-imidazol-4-one | C9H14N2O | 详情 | 详情 | |
| (IV) | 15538 | 5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-trityl-2H-1,2,3,4-tetraazole | 124750-51-2 | C33H25BrN4 | 详情 | 详情 |
| (V) | 18741 | 5-(1-methylethylidene)-2-propyl-3-[[2'-(1-trityl-1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-3,5-dihydro-4H-imidazol-4-one | C42H38N6O | 详情 | 详情 |
Extended Information