【结 构 式】 |
【分子编号】18109 【品名】ethyl 2-[[(cyclohexylamino)carbonyl]amino]-4,5-dimethyl-3-thiophenecarboxylate 【CA登记号】 |
【 分 子 式 】C16H24N2O3S 【 分 子 量 】324.44424 【元素组成】C 59.23% H 7.46% N 8.63% O 14.79% S 9.88% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)Condensation of aminothiophene (I) with cyclohexyl isocyanate (II) in refluxing toluene afforded urea (III). Then, treatment with ethanolic KOH gave the pyrimidine dione system.
【1】 Romeo, G.; et al.; Synthesis of new thieno[2,3-d]pyrimidine-2,4(1H, 3H)-diones with analgesic and anti-inflammatory activities. Arzneim-Forsch Drug Res 1998, 48, 2, 167-172. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 18107 | ethyl 2-amino-4,5-dimethyl-3-thiophenecarboxylate | 4815-24-1 | C9H13NO2S | 详情 | 详情 |
(II) | 18108 | 1-isocyanatocyclohexane; cyclohexyl isocyanate | 3173-53-3 | C7H11NO | 详情 | 详情 |
(III) | 18109 | ethyl 2-[[(cyclohexylamino)carbonyl]amino]-4,5-dimethyl-3-thiophenecarboxylate | C16H24N2O3S | 详情 | 详情 |
Extended Information