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【结 构 式】

【分子编号】18109

【品名】ethyl 2-[[(cyclohexylamino)carbonyl]amino]-4,5-dimethyl-3-thiophenecarboxylate

【CA登记号】

【 分 子 式 】C16H24N2O3S

【 分 子 量 】324.44424

【元素组成】C 59.23% H 7.46% N 8.63% O 14.79% S 9.88%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Condensation of aminothiophene (I) with cyclohexyl isocyanate (II) in refluxing toluene afforded urea (III). Then, treatment with ethanolic KOH gave the pyrimidine dione system.

1 Romeo, G.; et al.; Synthesis of new thieno[2,3-d]pyrimidine-2,4(1H, 3H)-diones with analgesic and anti-inflammatory activities. Arzneim-Forsch Drug Res 1998, 48, 2, 167-172.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 18107 ethyl 2-amino-4,5-dimethyl-3-thiophenecarboxylate 4815-24-1 C9H13NO2S 详情 详情
(II) 18108 1-isocyanatocyclohexane; cyclohexyl isocyanate 3173-53-3 C7H11NO 详情 详情
(III) 18109 ethyl 2-[[(cyclohexylamino)carbonyl]amino]-4,5-dimethyl-3-thiophenecarboxylate C16H24N2O3S 详情 详情
Extended Information